In vivo techniques and analysis

J. A. Angus, C. E. Wright, K. Sudhir, G. J. Jennings

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

When scientists aim to understand the mechanism of action of a drug on the vascular system, they will seek the ultimate experiment in a chosen test system stripped of its layers of complex interactions to maximize analytical power and minimize external influences. With such a controlled assay design, scientists may achieve some measure of analytical certainty that their vascular drug is behaving in a direct predictable manner. Such a bioassay system may be a smooth muscle cell membrane preparation, cell culture system, or isolated large or small artery mounted in a myograph or organ chamber. But in the end, these scientists will, theoretically at least, have to extrapolate their findings to the more integrated system of a vascular bed and ultimately the human circulation.

Original languageEnglish
Title of host publicationThe Pharmacology of Vascular Smooth Muscle
EditorsC. J. Garland, J. A. Angus
Place of PublicationNew York NY USA
PublisherOxford University Press, USA
Chapter4
Pages71-102
Number of pages33
ISBN (Electronic)9780191724671
ISBN (Print)9780192623874
DOIs
Publication statusPublished - 1996
Externally publishedYes

Keywords

  • Analytical power
  • Assay design
  • Bioassays
  • Myograph
  • Organ chambers
  • Vascular system

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