Abstract
When scientists aim to understand the mechanism of action of a drug on the vascular system, they will seek the ultimate experiment in a chosen test system stripped of its layers of complex interactions to maximize analytical power and minimize external influences. With such a controlled assay design, scientists may achieve some measure of analytical certainty that their vascular drug is behaving in a direct predictable manner. Such a bioassay system may be a smooth muscle cell membrane preparation, cell culture system, or isolated large or small artery mounted in a myograph or organ chamber. But in the end, these scientists will, theoretically at least, have to extrapolate their findings to the more integrated system of a vascular bed and ultimately the human circulation.
Original language | English |
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Title of host publication | The Pharmacology of Vascular Smooth Muscle |
Editors | C. J. Garland, J. A. Angus |
Place of Publication | New York NY USA |
Publisher | Oxford University Press, USA |
Chapter | 4 |
Pages | 71-102 |
Number of pages | 33 |
ISBN (Electronic) | 9780191724671 |
ISBN (Print) | 9780192623874 |
DOIs | |
Publication status | Published - 1996 |
Externally published | Yes |
Keywords
- Analytical power
- Assay design
- Bioassays
- Myograph
- Organ chambers
- Vascular system