In vivo properties of a cloned K88 adherence antigen determinant

G. Dougan, R. Sellwood, D. Maskell, K. Sweeney, F. Y. Liew, J. Beesley, C. Hormaeche

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An Escherichia coli strain of serotype O9:K36:H19 harboring the K88 recombinant plasmid pMK005 was able to efficiently colonize the small bowel of young piglets after oral infection. The strain expressed K88 antigen in vivo, and bacteria were detected in close association with the surface of the intestinal villi. Mice infected orally or intravenously with attenuated Salmonella typhimurium SL3261 harboring pMK005 were well protected against subsequent challenge with the highly virulent S. typhimurium SL1344. Anti-K88 antibodies were detected in the serum of mice immunized with SL3261(pMK005).

Original languageEnglish
Pages (from-to)344-347
Number of pages4
JournalInfection and Immunity
Issue number1
Publication statusPublished - 25 Jun 1986
Externally publishedYes

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Dougan, G., Sellwood, R., Maskell, D., Sweeney, K., Liew, F. Y., Beesley, J., & Hormaeche, C. (1986). In vivo properties of a cloned K88 adherence antigen determinant. Infection and Immunity, 52(1), 344-347.