In vivo characterization and numerical simulation of prostate properties for non-thermal irreversible electroporation ablation

Robert E Neal II; Jeremy Millar; Helen Kavnoudias; Peter Royce; Franklin Lawrence Rosenfeldt; Alan Pham; Ryan L Smith; Rafael V Davalos; Kenneth R Thomson

doi:10.1002/pros.22760

In vivo characterization and numerical simulation of prostate properties for non-thermal irreversible electroporation ablation

Robert E Neal II, Jeremy Millar, Helen Kavnoudias, Peter Royce, Franklin Lawrence Rosenfeldt, Alan Pham, Ryan L Smith, Rafael V Davalos, Kenneth R Thomson

Surgery Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

93 Citations (Scopus)

Abstract

Irreversible electroporation (IRE) delivers brief electric pulses to attain non-thermal focal ablation that spares vasculature and other sensitive systems. It is a promising prostate cancer treatment due to sparing of the tissues associated with morbidity risk from conventional therapies. IRE effects depend on electric field strength and tissue properties. These characteristics are organ-dependent, affecting IRE treatment outcomes. This study characterizes the relevant properties to improve treatment planning and outcome predictions for IRE prostate cancer treatment.

Original language	English
Pages (from-to)	458 - 468
Number of pages	11
Journal	The Prostate
Volume	74
Issue number	5
DOIs	https://doi.org/10.1002/pros.22760
Publication status	Published - 2014

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10.1002/pros.22760

Cite this

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abstract = "Irreversible electroporation (IRE) delivers brief electric pulses to attain non-thermal focal ablation that spares vasculature and other sensitive systems. It is a promising prostate cancer treatment due to sparing of the tissues associated with morbidity risk from conventional therapies. IRE effects depend on electric field strength and tissue properties. These characteristics are organ-dependent, affecting IRE treatment outcomes. This study characterizes the relevant properties to improve treatment planning and outcome predictions for IRE prostate cancer treatment.",

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AU - Neal II, Robert E

AU - Millar, Jeremy

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AU - Royce, Peter

AU - Rosenfeldt, Franklin Lawrence

AU - Pham, Alan

AU - Smith, Ryan L

AU - Davalos, Rafael V

AU - Thomson, Kenneth R

PY - 2014

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AB - Irreversible electroporation (IRE) delivers brief electric pulses to attain non-thermal focal ablation that spares vasculature and other sensitive systems. It is a promising prostate cancer treatment due to sparing of the tissues associated with morbidity risk from conventional therapies. IRE effects depend on electric field strength and tissue properties. These characteristics are organ-dependent, affecting IRE treatment outcomes. This study characterizes the relevant properties to improve treatment planning and outcome predictions for IRE prostate cancer treatment.

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U2 - 10.1002/pros.22760

DO - 10.1002/pros.22760

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JO - The Prostate

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ER -

In vivo characterization and numerical simulation of prostate properties for non-thermal irreversible electroporation ablation

Abstract

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