In Vivo Biosensing: Progress and Perspectives

Guoxin Rong, Simon R. Corrie, Heather A. Clark

Research output: Contribution to journalReview ArticleResearchpeer-review

50 Citations (Scopus)

Abstract

In vivo biosensors are emerging as powerful tools in biomedical research and diagnostic medicine. Distinct from "labels" or "imaging", in vivo biosensors are designed for continuous and long-term monitoring of target analytes in real biological systems and should be selective, sensitive, reversible and biocompatible. Due to the challenges associated with meeting all of the analytical requirements, we found relatively few reports of research groups demonstrating devices that meet the strict definition in vivo. However, we identified several case studies and a range of emerging materials likely to lead to significant developments in the field.

Original languageEnglish
Pages (from-to)327-338
Number of pages12
JournalACS Sensors
Volume2
Issue number3
DOIs
Publication statusPublished - 24 Mar 2017

Keywords

  • biosensor
  • continuous
  • dynamic range
  • implantable
  • in vivo
  • nanoparticle
  • reversible
  • sensor
  • signal transduction
  • specificity

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