In vivo activity of benzoyl ester clerodane diterpenoid derivatives from dodonaea polyandra

Bradley S Simpson, David J Claudie, Jacobus P. Gerber, Simon M Pyke, Jiping Wang, Ross A. McKinnon, Susan J Semple

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23 Citations (Scopus)

Abstract

Four new benzoyl ester clerodane diterpenoids, 15,16-epoxy-8α- (benzoyloxy)methylcleroda-3,13(16),14-trien-18-oic acid (1), 15,16-epoxy-8α-(benzoyloxy)methyl-2α-hydroxycleroda-3,13(16), 14-trien-18-oic acid (2), 15,16-epoxy-8α-(benzoyloxy)methyl-2-oxocleroda- 3,13(16),14-trien-18-oic acid (3), and 15,16-epoxy-2α-benzoyloxycleroda-3, 13(16),14-trien-18-oic acid (4), have been isolated from the leaves and stems of Dodonaea polyandra. The anti-inflammatory activities of compounds 1, 2, and 4 were evaluated by means of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema. Compounds 2 and 4 exhibited maximum inhibition of inflammation (70-76%) at doses of 0.22 and 0.9 μmol/ear, respectively. Modest activity (45% inhibition) was maintained at nanomole/ear doses.

Original languageEnglish
Pages (from-to)650-657
Number of pages8
JournalJournal of Natural Products
Volume74
Issue number4
DOIs
Publication statusPublished - 25 Apr 2011
Externally publishedYes

Cite this

Simpson, B. S., Claudie, D. J., Gerber, J. P., Pyke, S. M., Wang, J., McKinnon, R. A., & Semple, S. J. (2011). In vivo activity of benzoyl ester clerodane diterpenoid derivatives from dodonaea polyandra. Journal of Natural Products, 74(4), 650-657. https://doi.org/10.1021/np100701s