In vitro susceptibility of recent Chlamydia trachomatis clinical isolates to the CtHtrA inhibitor JO146

Vanissa A. Ong, Amba Lawrence, Peter Timms, Lenka A. Vodstrcil, Sepehr N Tabrizi, Kenneth W Beagley, John A. Allan, Jane S. Hocking, Wilhelmina M Huston

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Abstract

The present study aimed to establish if a previously identified Chlamydia trachomatis HtrA (CtHtrA) inhibitor, JO146, is effective against currently circulating clinical isolates to validate if CtHtrA is a clinically relevant target for future therapeutic development. Inhibition of CtHtrA during the middle of the chlamydial replicative cycle until the completion of the cycle resulted in loss of infectious progeny for six unique clinical isolates representing different serovars. This supports the potential for CtHtrA to be a clinically relevant target for development of new therapeutics and suggests the importance of further investigation of JO146 as a lead compound.

Original languageEnglish
Pages (from-to)738-744
Number of pages7
JournalMicrobes and Infection
Volume17
Issue number11-12
DOIs
Publication statusPublished - 1 Nov 2015
Externally publishedYes

Keywords

  • Chlamydia
  • Clinical isolate
  • HtrA
  • Inhibitor

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