In vitro hemocompatibility and cytotoxicity study of poly(2-methyl-2- oxazoline) for biomedical applications

Marius Bauer, Susann Schroeder, Lutz Tauhardt, Kristian Kempe, Ulrich S. Schubert, Dagmar Fischer

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52 Citations (Scopus)

Abstract

Since poly(2-methyl-2-oxazolines) (PMeOx) attract high attention for the potential use in drug delivery, cytotoxicity, and hemocompatibility of a set of PMeOxs with molar masses in the range from 2 to 20 kDa are systematically investigated under standardized conditions in terms of molar mass, concentration and time dependency. PMeOx polymers are well tolerated in red blood cell aggregation and hemolysis assays without any damaging effects even at high concentrations up to 80 mg/mL. Only in long term cytotoxicity tests PMeOx polymers moderately influence cell viability in a time, concentration, and molar mass dependent manner. Referring to these results it can be concluded that PEtOx could be promising nonionic hydrophilic polymers for many biomedical applications without any cyto- and hemotoxic effects at typically used therapeutic doses.

Original languageEnglish
Pages (from-to)1816-1821
Number of pages6
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume51
Issue number8
DOIs
Publication statusPublished - 15 Apr 2013
Externally publishedYes

Keywords

  • biocompatibility
  • hemocompatibility
  • hydrophilic polymer
  • poly(2-methyl-2- oxazoline)
  • ring-opening poly-merization

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