In-vitro evaluation of cardiac energetics and coronary flow with volume displacement and rotary blood pumps

L. Eric Wu, Geoff Tansley, F. John Fraser, D. Shaun Gregory

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther


Bridge to recovery with left ventricular assist device (LVAD) support has been more prominent with volume displacement pumps (VDPs) than with rotary blood pumps (RBPs), which may be due to VDPs providing greater ventricular unloading and coronary artery flow. To compare ventricular unloading and coronary flow of VDPs and RBPs in a repeatable environment, a physiologic coronary circulation was added to a pre-existing mock circulatory loop. In this study, a physiologic coronary circulation, mimicking a healthy or diseased auto-regulatory response was implemented in a mock circulatory loop. Using the mock circulation loop, a VDP with original (Björk-Shiley) and then replacement (jellyfish) valves was operated in clinically recommended modes and compared to full and partial assist RBP operating at constant speed and rapid speed modulated modes. The Björk-Shiley VDP resulted in increased pressure-volume area, which resulted in greater coronary artery flow when compared to the improved jellyfish valves. Full assist RBP support reduced left ventricular stroke work, pressure-volume area and coronary flow compared to partial assist, whilst the effect of speed modulation modes was not as significant. Of all LVAD operating modes, the counter-pulsed VDP with jellyfish valves demonstrated the greatest reduction in pressure-volume area and improved coronary flow. This study provides a basis for further investigation into RBP speed modulation profiles to match the improved haemodynamic performance of VDPs.

Original languageEnglish
Title of host publication40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
EditorsGregg Suaning, Olaf Dossel
Place of PublicationDanvers MA USA
PublisherIEEE, Institute of Electrical and Electronics Engineers
Number of pages5
ISBN (Electronic)9781538636466, 9781538636459
ISBN (Print)9781538636473
Publication statusPublished - 26 Oct 2018
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2018 - Honolulu, United States of America
Duration: 17 Jul 201821 Jul 2018
Conference number: 40th (Proceedings)


ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2018
Abbreviated titleEMBC 2018
Country/TerritoryUnited States of America
Internet address

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