In vitro antioxidant activity of ethanolic extract of Mucuna pruriens (L.) DC. Seeds

J. M. Sonpetkar, S. S. Nipate, P A Shenoy, P. D. Chaudhari

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Mucuna pruriens Linn (Fabaceae) which grows abundantly in India finds use in the endigenous system of medicine for a variety of purposes, as an uterine
stimulant, in dysentery, as nerve tonic, diuretic and aphrodisiac. The aim of this study was to assess the in vitro potential of ethanolic seed extract of Mucuna
as a natural antioxidant. Ethanolic extract of seeds of Mucuna pruriens exhibited its scavenging effect in concentration dependent manner on 2, 2-
diphenyl-1-picrylhydrazyl (DPPH), hydroxyl radical, nitric oxide, superoxide and reducing power. The antioxidant activities were compared with standard
antioxidant ascorbic acid. In all the test, a significant correlation existed between concentrations of the extract and percentage inhibition of free radicals. The
findings of the present study suggested that Mucuna pruriens could be a potential natural source of antioxidants and could have greater importance as
therapeutic agent in preventing or slowing oxidative stress related degenerative diseases.
Original languageEnglish
Pages (from-to)2769-2772
Number of pages4
JournalJournal of Pharmacy Research
Issue number5
Publication statusPublished - 2012
Externally publishedYes

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