In vitro activity of SCH-34343, a new penam, and other antimicrobial agents against clinical isolates from cancer patients

Kenneth V.I. Rolston, Maria Elena Alvarez, Jennifer F. Hoy, Helen C. Alderman, Dah Hsi Ho, Gerald P. Bodey

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2 Citations (Scopus)

Abstract

The in vitro activity of SCH-34343, a new penam antibiotic, was tested against gram-positive and gram-negative isolates from cancer patients, and compared to that of 7 other antimicrobial agents. SCH-34343 was extremely active against the Enlerobacleriaceae with MIC90S ranging from 0.39 to 6.25 μg/ml for Citrohacter spp. Enterobacter spp., Escherichia coli, Klebsiella spp., Proteus spp. and Serratia marcescens. It was less active against Acinetobacter spp. (MICyo 6.25-12.5 μg/ml) and had poor activity against Pseudomonas aeruginosa. Among gram-positive isolates group A and G /f-hemolytic Streptococci were extremely susceptible to SCH-34343 (MIC900.025-0.05 μg/ml). Good activity against methicillin-susceptible coagulase-positive and coagulase-negative Staphylococci and Listeria monocytogenes, and moderate activity against Enterococci was also seen.

Original languageEnglish
Pages (from-to)506-514
Number of pages9
JournalChemotherapy
Volume32
Issue number6
DOIs
Publication statusPublished - 1 Jan 1986

Keywords

  • Broad antibacterial spectrum
  • New penam
  • SCH-34343

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