In vitro activity of SCH-34343, a new penam, and other antimicrobial agents against clinical isolates from cancer patients

Kenneth V.I. Rolston; Maria Elena Alvarez; Jennifer F. Hoy; Helen C. Alderman; Dah Hsi Ho; Gerald P. Bodey

doi:10.1159/000238460

In vitro activity of SCH-34343, a new penam, and other antimicrobial agents against clinical isolates from cancer patients

Kenneth V.I. Rolston, Maria Elena Alvarez, Jennifer F. Hoy, Helen C. Alderman, Dah Hsi Ho, Gerald P. Bodey

Infectious Diseases

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

The in vitro activity of SCH-34343, a new penam antibiotic, was tested against gram-positive and gram-negative isolates from cancer patients, and compared to that of 7 other antimicrobial agents. SCH-34343 was extremely active against the Enlerobacleriaceae with MIC₉₀S ranging from 0.39 to 6.25 μg/ml for Citrohacter spp. Enterobacter spp., Escherichia coli, Klebsiella spp., Proteus spp. and Serratia marcescens. It was less active against Acinetobacter spp. (MICyo 6.25-12.5 μg/ml) and had poor activity against Pseudomonas aeruginosa. Among gram-positive isolates group A and G /f-hemolytic Streptococci were extremely susceptible to SCH-34343 (MIC₉₀0.025-0.05 μg/ml). Good activity against methicillin-susceptible coagulase-positive and coagulase-negative Staphylococci and Listeria monocytogenes, and moderate activity against Enterococci was also seen.

Original language	English
Pages (from-to)	506-514
Number of pages	9
Journal	Chemotherapy
Volume	32
Issue number	6
DOIs	https://doi.org/10.1159/000238460
Publication status	Published - 1 Jan 1986

Keywords

Broad antibacterial spectrum
New penam
SCH-34343

Access to Document

10.1159/000238460

Link to publication in Scopus

Cite this

@article{1cef6f8162ba400d8e1232c61d5a99f6,

title = "In vitro activity of SCH-34343, a new penam, and other antimicrobial agents against clinical isolates from cancer patients",

abstract = "The in vitro activity of SCH-34343, a new penam antibiotic, was tested against gram-positive and gram-negative isolates from cancer patients, and compared to that of 7 other antimicrobial agents. SCH-34343 was extremely active against the Enlerobacleriaceae with MIC90S ranging from 0.39 to 6.25 μg/ml for Citrohacter spp. Enterobacter spp., Escherichia coli, Klebsiella spp., Proteus spp. and Serratia marcescens. It was less active against Acinetobacter spp. (MICyo 6.25-12.5 μg/ml) and had poor activity against Pseudomonas aeruginosa. Among gram-positive isolates group A and G /f-hemolytic Streptococci were extremely susceptible to SCH-34343 (MIC900.025-0.05 μg/ml). Good activity against methicillin-susceptible coagulase-positive and coagulase-negative Staphylococci and Listeria monocytogenes, and moderate activity against Enterococci was also seen.",

keywords = "Broad antibacterial spectrum, New penam, SCH-34343",

author = "Rolston, {Kenneth V.I.} and Alvarez, {Maria Elena} and Hoy, {Jennifer F.} and Alderman, {Helen C.} and Ho, {Dah Hsi} and Bodey, {Gerald P.}",

year = "1986",

month = jan,

day = "1",

doi = "10.1159/000238460",

language = "English",

volume = "32",

pages = "506--514",

journal = "Chemotherapy",

issn = "0009-3157",

publisher = "Karger",

number = "6",

}

In vitro activity of SCH-34343, a new penam, and other antimicrobial agents against clinical isolates from cancer patients. / Rolston, Kenneth V.I.; Alvarez, Maria Elena; Hoy, Jennifer F.; Alderman, Helen C.; Ho, Dah Hsi; Bodey, Gerald P.

In: Chemotherapy, Vol. 32, No. 6, 01.01.1986, p. 506-514.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - In vitro activity of SCH-34343, a new penam, and other antimicrobial agents against clinical isolates from cancer patients

AU - Rolston, Kenneth V.I.

AU - Alvarez, Maria Elena

AU - Hoy, Jennifer F.

AU - Alderman, Helen C.

AU - Ho, Dah Hsi

AU - Bodey, Gerald P.

PY - 1986/1/1

Y1 - 1986/1/1

N2 - The in vitro activity of SCH-34343, a new penam antibiotic, was tested against gram-positive and gram-negative isolates from cancer patients, and compared to that of 7 other antimicrobial agents. SCH-34343 was extremely active against the Enlerobacleriaceae with MIC90S ranging from 0.39 to 6.25 μg/ml for Citrohacter spp. Enterobacter spp., Escherichia coli, Klebsiella spp., Proteus spp. and Serratia marcescens. It was less active against Acinetobacter spp. (MICyo 6.25-12.5 μg/ml) and had poor activity against Pseudomonas aeruginosa. Among gram-positive isolates group A and G /f-hemolytic Streptococci were extremely susceptible to SCH-34343 (MIC900.025-0.05 μg/ml). Good activity against methicillin-susceptible coagulase-positive and coagulase-negative Staphylococci and Listeria monocytogenes, and moderate activity against Enterococci was also seen.

AB - The in vitro activity of SCH-34343, a new penam antibiotic, was tested against gram-positive and gram-negative isolates from cancer patients, and compared to that of 7 other antimicrobial agents. SCH-34343 was extremely active against the Enlerobacleriaceae with MIC90S ranging from 0.39 to 6.25 μg/ml for Citrohacter spp. Enterobacter spp., Escherichia coli, Klebsiella spp., Proteus spp. and Serratia marcescens. It was less active against Acinetobacter spp. (MICyo 6.25-12.5 μg/ml) and had poor activity against Pseudomonas aeruginosa. Among gram-positive isolates group A and G /f-hemolytic Streptococci were extremely susceptible to SCH-34343 (MIC900.025-0.05 μg/ml). Good activity against methicillin-susceptible coagulase-positive and coagulase-negative Staphylococci and Listeria monocytogenes, and moderate activity against Enterococci was also seen.

KW - Broad antibacterial spectrum

KW - New penam

KW - SCH-34343

UR - http://www.scopus.com/inward/record.url?scp=0022979406&partnerID=8YFLogxK

U2 - 10.1159/000238460

DO - 10.1159/000238460

M3 - Article

C2 - 3100147

AN - SCOPUS:0022979406

VL - 32

SP - 506

EP - 514

JO - Chemotherapy

JF - Chemotherapy

SN - 0009-3157

IS - 6

ER -