In vitro activity of SCH-34343, a new penam, and other antimicrobial agents against clinical isolates from cancer patients

Kenneth V.I. Rolston, Maria Elena Alvarez, Jennifer F. Hoy, Helen C. Alderman, Dah Hsi Ho, Gerald P. Bodey

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)


The in vitro activity of SCH-34343, a new penam antibiotic, was tested against gram-positive and gram-negative isolates from cancer patients, and compared to that of 7 other antimicrobial agents. SCH-34343 was extremely active against the Enlerobacleriaceae with MIC90S ranging from 0.39 to 6.25 μg/ml for Citrohacter spp. Enterobacter spp., Escherichia coli, Klebsiella spp., Proteus spp. and Serratia marcescens. It was less active against Acinetobacter spp. (MICyo 6.25-12.5 μg/ml) and had poor activity against Pseudomonas aeruginosa. Among gram-positive isolates group A and G /f-hemolytic Streptococci were extremely susceptible to SCH-34343 (MIC900.025-0.05 μg/ml). Good activity against methicillin-susceptible coagulase-positive and coagulase-negative Staphylococci and Listeria monocytogenes, and moderate activity against Enterococci was also seen.

Original languageEnglish
Pages (from-to)506-514
Number of pages9
Issue number6
Publication statusPublished - 1 Jan 1986


  • Broad antibacterial spectrum
  • New penam
  • SCH-34343

Cite this