TY - JOUR
T1 - In-vitro activity of sch 34343, a new penam, against gram-positive isolates from cancer patients
AU - Rolston, Kenneth V.I.
AU - Alvarez, Maria Elena
AU - Hoy, Jennifer F.
AU - Alderman, Helen C.
AU - Ho, Dah Hsi
AU - Bodey, Gerald P.
PY - 1986/8/1
Y1 - 1986/8/1
N2 - The in-vitro activity of Sch 34343, a new penam antibiotic, was tested against 257 Gram-positive isolates from cancer patients, and compared with that of imipenem and amifloxacin. Sch 34343 was extremely active against β-haemolytic streptococci (Lancefield groups A, B and G) with MIC90s ranging from 0.025 to 0.05 mg/l. It was also active against methicillin-susceptible Staphylococcus aureus and had variable activity against coagulase-negative staphylococci. MIC90 for Listeria monocytogenes was 0.78 mg/l and 84% of enterococcal isolates were inhibited by 6.25 mg/l.
AB - The in-vitro activity of Sch 34343, a new penam antibiotic, was tested against 257 Gram-positive isolates from cancer patients, and compared with that of imipenem and amifloxacin. Sch 34343 was extremely active against β-haemolytic streptococci (Lancefield groups A, B and G) with MIC90s ranging from 0.025 to 0.05 mg/l. It was also active against methicillin-susceptible Staphylococcus aureus and had variable activity against coagulase-negative staphylococci. MIC90 for Listeria monocytogenes was 0.78 mg/l and 84% of enterococcal isolates were inhibited by 6.25 mg/l.
UR - http://www.scopus.com/inward/record.url?scp=0022496391&partnerID=8YFLogxK
U2 - 10.1093/jac/18.2.159
DO - 10.1093/jac/18.2.159
M3 - Article
C2 - 3093447
AN - SCOPUS:0022496391
VL - 18
SP - 159
EP - 162
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
SN - 0305-7453
IS - 2
ER -