In situ observation on particle formation process via single droplet drying apparatus: Effects of precursor composition on particle morphology

Nan Fu, Winston Duo Wu, Ming Yu, Fei Tzhung Moo, Meng Wai Woo, Cordelia Selomulya, Xiao Dong Chen

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10 Citations (Scopus)


RS/silica composite precursor containing either Rhodamine B or sucrose as model drug was dried in a single droplet drying apparatus. Microparticles with distinct core-shell structure were produced by one-step drying for all compositions, while Rhodamine B showed uneven distribution in core and shell regions. At 5% (w/w) loading, it influenced shell formation process by producing dispersible initial shell and altered particle surface morphology into wrinkling appearance, while similar effects were not observed for sucrose. Decreasing the loading to 0.017% reduced the influence. The observations might be attributed to the properties of Rhodamine B, which affect its migration behaviour during drying.
Original languageEnglish
Pages (from-to)1700-1708
Number of pages9
JournalDrying Technology
Issue number14
Publication statusPublished - 25 Oct 2016


  • Core-shell microparticles
  • Drug carrier
  • Model drug
  • Solutes migration
  • Spray drying

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