Abstract
RS/silica composite precursor containing either Rhodamine B or sucrose as model drug was dried in a single droplet drying apparatus. Microparticles with distinct core-shell structure were produced by one-step drying for all compositions, while Rhodamine B showed uneven distribution in core and shell regions. At 5% (w/w) loading, it influenced shell formation process by producing dispersible initial shell and altered particle surface morphology into wrinkling appearance, while similar effects were not observed for sucrose. Decreasing the loading to 0.017% reduced the influence. The observations might be attributed to the properties of Rhodamine B, which affect its migration behaviour during drying.
Original language | English |
---|---|
Pages (from-to) | 1700-1708 |
Number of pages | 9 |
Journal | Drying Technology |
Volume | 34 |
Issue number | 14 |
DOIs | |
Publication status | Published - 25 Oct 2016 |
Keywords
- Core-shell microparticles
- Drug carrier
- Model drug
- Solutes migration
- Spray drying