In situ observation on particle formation process via single droplet drying apparatus: Effects of precursor composition on particle morphology

Nan Fu; Winston Duo Wu; Ming Yu; Fei Tzhung Moo; Meng Wai Woo; Cordelia Selomulya; Xiao Dong Chen

doi:10.1080/07373937.2016.1186685

In situ observation on particle formation process via single droplet drying apparatus: Effects of precursor composition on particle morphology

Nan Fu, Winston Duo Wu, Ming Yu, Fei Tzhung Moo, Meng Wai Woo, Cordelia Selomulya, Xiao Dong Chen

Chemical & Biological Engineering

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

Abstract

RS/silica composite precursor containing either Rhodamine B or sucrose as model drug was dried in a single droplet drying apparatus. Microparticles with distinct core-shell structure were produced by one-step drying for all compositions, while Rhodamine B showed uneven distribution in core and shell regions. At 5% (w/w) loading, it influenced shell formation process by producing dispersible initial shell and altered particle surface morphology into wrinkling appearance, while similar effects were not observed for sucrose. Decreasing the loading to 0.017% reduced the influence. The observations might be attributed to the properties of Rhodamine B, which affect its migration behaviour during drying.

Original language	English
Pages (from-to)	1700-1708
Number of pages	9
Journal	Drying Technology
Volume	34
Issue number	14
DOIs	https://doi.org/10.1080/07373937.2016.1186685
Publication status	Published - 25 Oct 2016

Keywords

Core-shell microparticles
Drug carrier
Model drug
Solutes migration
Spray drying

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10.1080/07373937.2016.1186685

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title = "In situ observation on particle formation process via single droplet drying apparatus: Effects of precursor composition on particle morphology",

abstract = "RS/silica composite precursor containing either Rhodamine B or sucrose as model drug was dried in a single droplet drying apparatus. Microparticles with distinct core-shell structure were produced by one-step drying for all compositions, while Rhodamine B showed uneven distribution in core and shell regions. At 5% (w/w) loading, it influenced shell formation process by producing dispersible initial shell and altered particle surface morphology into wrinkling appearance, while similar effects were not observed for sucrose. Decreasing the loading to 0.017% reduced the influence. The observations might be attributed to the properties of Rhodamine B, which affect its migration behaviour during drying.",

keywords = "Core-shell microparticles, Drug carrier, Model drug, Solutes migration, Spray drying",

author = "Nan Fu and Wu, {Winston Duo} and Ming Yu and Moo, {Fei Tzhung} and Woo, {Meng Wai} and Cordelia Selomulya and Chen, {Xiao Dong}",

year = "2016",

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In situ observation on particle formation process via single droplet drying apparatus : Effects of precursor composition on particle morphology. / Fu, Nan; Wu, Winston Duo; Yu, Ming; Moo, Fei Tzhung; Woo, Meng Wai; Selomulya, Cordelia; Chen, Xiao Dong.

In: Drying Technology, Vol. 34, No. 14, 25.10.2016, p. 1700-1708.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - In situ observation on particle formation process via single droplet drying apparatus

T2 - Effects of precursor composition on particle morphology

AU - Fu, Nan

AU - Wu, Winston Duo

AU - Yu, Ming

AU - Moo, Fei Tzhung

AU - Woo, Meng Wai

AU - Selomulya, Cordelia

AU - Chen, Xiao Dong

PY - 2016/10/25

Y1 - 2016/10/25

N2 - RS/silica composite precursor containing either Rhodamine B or sucrose as model drug was dried in a single droplet drying apparatus. Microparticles with distinct core-shell structure were produced by one-step drying for all compositions, while Rhodamine B showed uneven distribution in core and shell regions. At 5% (w/w) loading, it influenced shell formation process by producing dispersible initial shell and altered particle surface morphology into wrinkling appearance, while similar effects were not observed for sucrose. Decreasing the loading to 0.017% reduced the influence. The observations might be attributed to the properties of Rhodamine B, which affect its migration behaviour during drying.

AB - RS/silica composite precursor containing either Rhodamine B or sucrose as model drug was dried in a single droplet drying apparatus. Microparticles with distinct core-shell structure were produced by one-step drying for all compositions, while Rhodamine B showed uneven distribution in core and shell regions. At 5% (w/w) loading, it influenced shell formation process by producing dispersible initial shell and altered particle surface morphology into wrinkling appearance, while similar effects were not observed for sucrose. Decreasing the loading to 0.017% reduced the influence. The observations might be attributed to the properties of Rhodamine B, which affect its migration behaviour during drying.

KW - Core-shell microparticles

KW - Drug carrier

KW - Model drug

KW - Solutes migration

KW - Spray drying

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U2 - 10.1080/07373937.2016.1186685

DO - 10.1080/07373937.2016.1186685

M3 - Article

VL - 34

SP - 1700

EP - 1708

JO - Drying Technology

JF - Drying Technology

SN - 0737-3937

IS - 14

ER -

In situ observation on particle formation process via single droplet drying apparatus: Effects of precursor composition on particle morphology

Abstract

Keywords

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