In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide-alkyne click reaction for tissue engineering

Vinh X. Truong, Matthew P. Ablett, Hamish T. J. Gilbert, James Bowen, Stephen M. Richardson, Judith A. Hoyland, Andrew P. Dove

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49 Citations (Scopus)


A water-soluble azide-functionalised chitosan was crosslinked with propiolic acid ester-functional poly(ethylene glycol) using copper-free click chemistry. The resultant hydrogel materials were formed within 5-60 min at 37 degrees celcius and resulted in mechanically robust materials with tuneable properties such as swelling, mechanical strength and degradation. Importantly, the hydrogels supported mesenchymal stem cell attachment and proliferation and were also non-toxic to encapsulated cells. As such these studies indicate that the hydrogels have potential to be used as injectable biomaterials for tissue engineering
Original languageEnglish
Pages (from-to)167-175
Number of pages9
JournalBiomaterials Science
Issue number2
Publication statusPublished - 2014
Externally publishedYes

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