In situ conjugation of dithiophenol maleimide polymers and oxytocin for stable and reversible polymer-peptide conjugates

Jennifer Susan Collins, Joji Tanaka, Paul J Wilson, Kristian Kempe, Thomas Paul Davis, Michelle Paula McIntosh, Michael Raymond Whittaker, David Mark Haddleton

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The in situ one-pot synthesis of peptide-polymer bioconjugates is reported. Conjugation occurs efficiently without the need for purification of dithiophenol maleimide functionalized polymer as a disulfide bridging agent for the therapeutic oxytocin. Conjugation of polymers was demonstrated to be reversible and to significantly improve the solution stability of oxytocin.
Original languageEnglish
Pages (from-to)633-638
Number of pages6
JournalBioconjugate Chemistry
Volume26
Issue number4
DOIs
Publication statusPublished - 2015

Cite this

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title = "In situ conjugation of dithiophenol maleimide polymers and oxytocin for stable and reversible polymer-peptide conjugates",
abstract = "The in situ one-pot synthesis of peptide-polymer bioconjugates is reported. Conjugation occurs efficiently without the need for purification of dithiophenol maleimide functionalized polymer as a disulfide bridging agent for the therapeutic oxytocin. Conjugation of polymers was demonstrated to be reversible and to significantly improve the solution stability of oxytocin.",
author = "Collins, {Jennifer Susan} and Joji Tanaka and Wilson, {Paul J} and Kristian Kempe and Davis, {Thomas Paul} and McIntosh, {Michelle Paula} and Whittaker, {Michael Raymond} and Haddleton, {David Mark}",
year = "2015",
doi = "10.1021/bc5006202",
language = "English",
volume = "26",
pages = "633--638",
journal = "Bioconjugate Chemistry",
issn = "1043-1802",
publisher = "American Chemical Society",
number = "4",

}

In situ conjugation of dithiophenol maleimide polymers and oxytocin for stable and reversible polymer-peptide conjugates. / Collins, Jennifer Susan; Tanaka, Joji; Wilson, Paul J; Kempe, Kristian; Davis, Thomas Paul; McIntosh, Michelle Paula; Whittaker, Michael Raymond; Haddleton, David Mark.

In: Bioconjugate Chemistry, Vol. 26, No. 4, 2015, p. 633-638.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - In situ conjugation of dithiophenol maleimide polymers and oxytocin for stable and reversible polymer-peptide conjugates

AU - Collins, Jennifer Susan

AU - Tanaka, Joji

AU - Wilson, Paul J

AU - Kempe, Kristian

AU - Davis, Thomas Paul

AU - McIntosh, Michelle Paula

AU - Whittaker, Michael Raymond

AU - Haddleton, David Mark

PY - 2015

Y1 - 2015

N2 - The in situ one-pot synthesis of peptide-polymer bioconjugates is reported. Conjugation occurs efficiently without the need for purification of dithiophenol maleimide functionalized polymer as a disulfide bridging agent for the therapeutic oxytocin. Conjugation of polymers was demonstrated to be reversible and to significantly improve the solution stability of oxytocin.

AB - The in situ one-pot synthesis of peptide-polymer bioconjugates is reported. Conjugation occurs efficiently without the need for purification of dithiophenol maleimide functionalized polymer as a disulfide bridging agent for the therapeutic oxytocin. Conjugation of polymers was demonstrated to be reversible and to significantly improve the solution stability of oxytocin.

U2 - 10.1021/bc5006202

DO - 10.1021/bc5006202

M3 - Article

VL - 26

SP - 633

EP - 638

JO - Bioconjugate Chemistry

JF - Bioconjugate Chemistry

SN - 1043-1802

IS - 4

ER -