In situ conjugation of dithiophenol maleimide polymers and oxytocin for stable and reversible polymer-peptide conjugates

Jennifer Susan Collins, Joji Tanaka, Paul J Wilson, Kristian Kempe, Thomas Paul Davis, Michelle Paula McIntosh, Michael Raymond Whittaker, David Mark Haddleton

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41 Citations (Scopus)

Abstract

The in situ one-pot synthesis of peptide-polymer bioconjugates is reported. Conjugation occurs efficiently without the need for purification of dithiophenol maleimide functionalized polymer as a disulfide bridging agent for the therapeutic oxytocin. Conjugation of polymers was demonstrated to be reversible and to significantly improve the solution stability of oxytocin.
Original languageEnglish
Pages (from-to)633-638
Number of pages6
JournalBioconjugate Chemistry
Volume26
Issue number4
DOIs
Publication statusPublished - 2015

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