In depth analysis of the Sox4 gene locus that consists of sense and natural antisense transcripts

King-Hwa Ling, Peter J. Brautigan, Sarah Moore, Rachel Fraser, Melody Pui-Yee Leong, Jia-Wen Leong, Shahidee Zainal Abidin, Han-Chung Lee, Pike-See Cheah, Joy M. Raison, Milena Babic, Young Kyung Lee, Tasman Daish, Deidre M. Mattiske, Jeffrey R. Mann, David L. Adelson, Paul Q. Thomas, Christopher N. Hahn, Hamish S. Scott

Research output: Contribution to journalArticleOtherpeer-review

Abstract

SRY (Sex Determining Region Y)-Box 4 or Sox4 is an important regulator of the pan-neuronal gene expression during post-mitotic cell differentiation within the mammalian brain. Sox4 gene locus has been previously characterized with multiple sense and overlapping natural antisense transcripts [1] and [2]. Here we provide accompanying data on various analyses performed and described in Ling et al. [2]. The data include a detail description of various features found at Sox4 gene locus, additional experimental data derived from RNA-Fluorescence in situ Hybridization (RNA-FISH), Western blotting, strand-specific reverse-transcription quantitative polymerase chain reaction (RT-qPCR), gain-of-function and in situ hybridization (ISH) experiments. All the additional data provided here support the existence of an endogenous small interfering- or PIWI interacting-like small RNA known as Sox4_sir3, which origin was found within the overlapping region consisting of a sense and a natural antisense transcript known as Sox4ot1.
Original languageEnglish
Pages (from-to)282-290
Number of pages9
JournalData in Brief
Volume7
DOIs
Publication statusPublished - Jun 2016

Keywords

  • endogenous siRNA
  • brain development
  • natural antisense transcripts

Cite this

Ling, K-H., Brautigan, P. J., Moore, S., Fraser, R., Leong, M. P-Y., Leong, J-W., ... Scott, H. S. (2016). In depth analysis of the Sox4 gene locus that consists of sense and natural antisense transcripts. Data in Brief, 7, 282-290. https://doi.org/10.1016/j.dib.2016.01.045
Ling, King-Hwa ; Brautigan, Peter J. ; Moore, Sarah ; Fraser, Rachel ; Leong, Melody Pui-Yee ; Leong, Jia-Wen ; Zainal Abidin, Shahidee ; Lee, Han-Chung ; Cheah, Pike-See ; Raison, Joy M. ; Babic, Milena ; Lee, Young Kyung ; Daish, Tasman ; Mattiske, Deidre M. ; Mann, Jeffrey R. ; Adelson, David L. ; Thomas, Paul Q. ; Hahn, Christopher N. ; Scott, Hamish S. / In depth analysis of the Sox4 gene locus that consists of sense and natural antisense transcripts. In: Data in Brief. 2016 ; Vol. 7. pp. 282-290.
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abstract = "SRY (Sex Determining Region Y)-Box 4 or Sox4 is an important regulator of the pan-neuronal gene expression during post-mitotic cell differentiation within the mammalian brain. Sox4 gene locus has been previously characterized with multiple sense and overlapping natural antisense transcripts [1] and [2]. Here we provide accompanying data on various analyses performed and described in Ling et al. [2]. The data include a detail description of various features found at Sox4 gene locus, additional experimental data derived from RNA-Fluorescence in situ Hybridization (RNA-FISH), Western blotting, strand-specific reverse-transcription quantitative polymerase chain reaction (RT-qPCR), gain-of-function and in situ hybridization (ISH) experiments. All the additional data provided here support the existence of an endogenous small interfering- or PIWI interacting-like small RNA known as Sox4_sir3, which origin was found within the overlapping region consisting of a sense and a natural antisense transcript known as Sox4ot1.",
keywords = "endogenous siRNA, brain development, natural antisense transcripts",
author = "King-Hwa Ling and Brautigan, {Peter J.} and Sarah Moore and Rachel Fraser and Leong, {Melody Pui-Yee} and Jia-Wen Leong and {Zainal Abidin}, Shahidee and Han-Chung Lee and Pike-See Cheah and Raison, {Joy M.} and Milena Babic and Lee, {Young Kyung} and Tasman Daish and Mattiske, {Deidre M.} and Mann, {Jeffrey R.} and Adelson, {David L.} and Thomas, {Paul Q.} and Hahn, {Christopher N.} and Scott, {Hamish S.}",
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Ling, K-H, Brautigan, PJ, Moore, S, Fraser, R, Leong, MP-Y, Leong, J-W, Zainal Abidin, S, Lee, H-C, Cheah, P-S, Raison, JM, Babic, M, Lee, YK, Daish, T, Mattiske, DM, Mann, JR, Adelson, DL, Thomas, PQ, Hahn, CN & Scott, HS 2016, 'In depth analysis of the Sox4 gene locus that consists of sense and natural antisense transcripts' Data in Brief, vol. 7, pp. 282-290. https://doi.org/10.1016/j.dib.2016.01.045

In depth analysis of the Sox4 gene locus that consists of sense and natural antisense transcripts. / Ling, King-Hwa; Brautigan, Peter J.; Moore, Sarah; Fraser, Rachel; Leong, Melody Pui-Yee; Leong, Jia-Wen; Zainal Abidin, Shahidee; Lee, Han-Chung; Cheah, Pike-See; Raison, Joy M.; Babic, Milena; Lee, Young Kyung; Daish, Tasman; Mattiske, Deidre M.; Mann, Jeffrey R.; Adelson, David L.; Thomas, Paul Q.; Hahn, Christopher N.; Scott, Hamish S.

In: Data in Brief, Vol. 7, 06.2016, p. 282-290.

Research output: Contribution to journalArticleOtherpeer-review

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T1 - In depth analysis of the Sox4 gene locus that consists of sense and natural antisense transcripts

AU - Ling, King-Hwa

AU - Brautigan, Peter J.

AU - Moore, Sarah

AU - Fraser, Rachel

AU - Leong, Melody Pui-Yee

AU - Leong, Jia-Wen

AU - Zainal Abidin, Shahidee

AU - Lee, Han-Chung

AU - Cheah, Pike-See

AU - Raison, Joy M.

AU - Babic, Milena

AU - Lee, Young Kyung

AU - Daish, Tasman

AU - Mattiske, Deidre M.

AU - Mann, Jeffrey R.

AU - Adelson, David L.

AU - Thomas, Paul Q.

AU - Hahn, Christopher N.

AU - Scott, Hamish S.

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N2 - SRY (Sex Determining Region Y)-Box 4 or Sox4 is an important regulator of the pan-neuronal gene expression during post-mitotic cell differentiation within the mammalian brain. Sox4 gene locus has been previously characterized with multiple sense and overlapping natural antisense transcripts [1] and [2]. Here we provide accompanying data on various analyses performed and described in Ling et al. [2]. The data include a detail description of various features found at Sox4 gene locus, additional experimental data derived from RNA-Fluorescence in situ Hybridization (RNA-FISH), Western blotting, strand-specific reverse-transcription quantitative polymerase chain reaction (RT-qPCR), gain-of-function and in situ hybridization (ISH) experiments. All the additional data provided here support the existence of an endogenous small interfering- or PIWI interacting-like small RNA known as Sox4_sir3, which origin was found within the overlapping region consisting of a sense and a natural antisense transcript known as Sox4ot1.

AB - SRY (Sex Determining Region Y)-Box 4 or Sox4 is an important regulator of the pan-neuronal gene expression during post-mitotic cell differentiation within the mammalian brain. Sox4 gene locus has been previously characterized with multiple sense and overlapping natural antisense transcripts [1] and [2]. Here we provide accompanying data on various analyses performed and described in Ling et al. [2]. The data include a detail description of various features found at Sox4 gene locus, additional experimental data derived from RNA-Fluorescence in situ Hybridization (RNA-FISH), Western blotting, strand-specific reverse-transcription quantitative polymerase chain reaction (RT-qPCR), gain-of-function and in situ hybridization (ISH) experiments. All the additional data provided here support the existence of an endogenous small interfering- or PIWI interacting-like small RNA known as Sox4_sir3, which origin was found within the overlapping region consisting of a sense and a natural antisense transcript known as Sox4ot1.

KW - endogenous siRNA

KW - brain development

KW - natural antisense transcripts

UR - http://www.ncbi.nlm.nih.gov/pubmed/26958646

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DO - 10.1016/j.dib.2016.01.045

M3 - Article

VL - 7

SP - 282

EP - 290

JO - Data in Brief

JF - Data in Brief

SN - 2352-3409

ER -