Improving vaccines by targeting antigens to dendritic cells

Research output: Contribution to journalReview ArticleResearchpeer-review

78 Citations (Scopus)

Abstract

A new approach to enhancing the effectiveness of vaccines is to deliver antigens selectively to dendritic cells (DC) in situ, via monoclonal antibodies specific for particular DC surface molecules. This can markedly enhance CTL responses and, via helper T cells, also enhance antibody responses. DC activation agents or adjuvants must also be administered for effective CTL responses, but in some cases good antibody responses can be obtained without adjuvants. Here we review the role of different DC subsets and different DC target molecules in obtaining enhanced immune responses.

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalExperimental and Molecular Medicine
Volume41
Issue number2
DOIs
Publication statusPublished - 28 Feb 2009
Externally publishedYes

Keywords

  • Adjuvants
  • Antibody formation
  • CLEC9a protein
  • DEC-205 receptor
  • Dendritic cells
  • Human
  • Immunologic
  • Vaccines

Cite this

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title = "Improving vaccines by targeting antigens to dendritic cells",
abstract = "A new approach to enhancing the effectiveness of vaccines is to deliver antigens selectively to dendritic cells (DC) in situ, via monoclonal antibodies specific for particular DC surface molecules. This can markedly enhance CTL responses and, via helper T cells, also enhance antibody responses. DC activation agents or adjuvants must also be administered for effective CTL responses, but in some cases good antibody responses can be obtained without adjuvants. Here we review the role of different DC subsets and different DC target molecules in obtaining enhanced immune responses.",
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Improving vaccines by targeting antigens to dendritic cells. / Shortman, Ken; Lahoud, Mireille H.; Caminschi, Irina.

In: Experimental and Molecular Medicine, Vol. 41, No. 2, 28.02.2009, p. 61-66.

Research output: Contribution to journalReview ArticleResearchpeer-review

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KW - DEC-205 receptor

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KW - Human

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