Improving understanding of chromatin regulatory proteins and potential implications for drug discovery

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Abstract

Many epigenetic-based therapeutics, including drugs such as histone deacetylase inhibitors, are now used in the clinic or are undergoing advanced clinical trials. The study of chromatin-modifying proteins has benefited from the rapid advances in high-throughput sequencing methods, the organized efforts of major consortiums and by individual groups to profile human epigenomes in diverse tissues and cell types. However, while such initiatives have carefully characterized healthy human tissue, disease epigenomes and drug-epigenome interactions remain very poorly understood. Reviewed here is how high-throughput sequencing improves our understanding of chromatin regulator proteins and the potential implications for the study of human disease and drug development and discovery.

Original languageEnglish
Pages (from-to)435-445
Number of pages11
JournalExpert Review of Proteomics
Volume13
Issue number4
DOIs
Publication statusPublished - 2 Apr 2016

Keywords

  • chromatin modifications
  • Epigenetics
  • HDAC inhibitors
  • high-throughput sequencing
  • histone acetylation

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