Improving the Recognition of, and Response to In-Hospital Sepsis

Research output: Contribution to journalReview ArticleResearchpeer-review

9 Citations (Scopus)

Abstract

Sepsis is an important cause of patient morbidity and mortality worldwide. Although the associated mortality seems to be decreasing, approximately 20 % of patients with organ dysfunction die in hospital. Since 1991 diagnostic criteria for sepsis focused on the systemic inflammatory response syndrome (SIRS). However, the utility of such criteria has been questioned, and alternative criteria have recently been proposed. It is likely that administration of early appropriate antibiotics and resolution of shock reduce sepsis-associated mortality. Accordingly, strategies need to be developed to improve the early recognition of, and response to patients with sepsis. Such system approaches may include improved acquisition and documentation of vital signs, enhanced recognition of shock, and integration of laboratory and microbiological results using clinical informatics. Hospitals should have guidelines for escalating care of septic patients, antibiotics stewardship programs, and systems to audit morbidity and mortality associated with sepsis.

Original languageEnglish
Article number20
Number of pages7
JournalCurrent Infectious Disease Reports
Volume18
Issue number7
DOIs
Publication statusPublished - Jul 2016

Keywords

  • Deteriorating patient
  • Early intervention
  • Rapid response team
  • Sepsis
  • Severe sepsis

Cite this

@article{74015c9e58c44a878aaad7a50551b71a,
title = "Improving the Recognition of, and Response to In-Hospital Sepsis",
abstract = "Sepsis is an important cause of patient morbidity and mortality worldwide. Although the associated mortality seems to be decreasing, approximately 20 {\%} of patients with organ dysfunction die in hospital. Since 1991 diagnostic criteria for sepsis focused on the systemic inflammatory response syndrome (SIRS). However, the utility of such criteria has been questioned, and alternative criteria have recently been proposed. It is likely that administration of early appropriate antibiotics and resolution of shock reduce sepsis-associated mortality. Accordingly, strategies need to be developed to improve the early recognition of, and response to patients with sepsis. Such system approaches may include improved acquisition and documentation of vital signs, enhanced recognition of shock, and integration of laboratory and microbiological results using clinical informatics. Hospitals should have guidelines for escalating care of septic patients, antibiotics stewardship programs, and systems to audit morbidity and mortality associated with sepsis.",
keywords = "Deteriorating patient, Early intervention, Rapid response team, Sepsis, Severe sepsis",
author = "Peter Chan and Sandra Peake and Rinaldo Bellomo and Daryl Jones",
year = "2016",
month = "7",
doi = "10.1007/s11908-016-0528-7",
language = "English",
volume = "18",
journal = "Current Infectious Disease Reports",
issn = "1523-3847",
publisher = "Springer-Verlag London Ltd.",
number = "7",

}

Improving the Recognition of, and Response to In-Hospital Sepsis. / Chan, Peter; Peake, Sandra; Bellomo, Rinaldo; Jones, Daryl.

In: Current Infectious Disease Reports, Vol. 18, No. 7, 20, 07.2016.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Improving the Recognition of, and Response to In-Hospital Sepsis

AU - Chan, Peter

AU - Peake, Sandra

AU - Bellomo, Rinaldo

AU - Jones, Daryl

PY - 2016/7

Y1 - 2016/7

N2 - Sepsis is an important cause of patient morbidity and mortality worldwide. Although the associated mortality seems to be decreasing, approximately 20 % of patients with organ dysfunction die in hospital. Since 1991 diagnostic criteria for sepsis focused on the systemic inflammatory response syndrome (SIRS). However, the utility of such criteria has been questioned, and alternative criteria have recently been proposed. It is likely that administration of early appropriate antibiotics and resolution of shock reduce sepsis-associated mortality. Accordingly, strategies need to be developed to improve the early recognition of, and response to patients with sepsis. Such system approaches may include improved acquisition and documentation of vital signs, enhanced recognition of shock, and integration of laboratory and microbiological results using clinical informatics. Hospitals should have guidelines for escalating care of septic patients, antibiotics stewardship programs, and systems to audit morbidity and mortality associated with sepsis.

AB - Sepsis is an important cause of patient morbidity and mortality worldwide. Although the associated mortality seems to be decreasing, approximately 20 % of patients with organ dysfunction die in hospital. Since 1991 diagnostic criteria for sepsis focused on the systemic inflammatory response syndrome (SIRS). However, the utility of such criteria has been questioned, and alternative criteria have recently been proposed. It is likely that administration of early appropriate antibiotics and resolution of shock reduce sepsis-associated mortality. Accordingly, strategies need to be developed to improve the early recognition of, and response to patients with sepsis. Such system approaches may include improved acquisition and documentation of vital signs, enhanced recognition of shock, and integration of laboratory and microbiological results using clinical informatics. Hospitals should have guidelines for escalating care of septic patients, antibiotics stewardship programs, and systems to audit morbidity and mortality associated with sepsis.

KW - Deteriorating patient

KW - Early intervention

KW - Rapid response team

KW - Sepsis

KW - Severe sepsis

UR - http://www.scopus.com/inward/record.url?scp=84971221986&partnerID=8YFLogxK

U2 - 10.1007/s11908-016-0528-7

DO - 10.1007/s11908-016-0528-7

M3 - Review Article

VL - 18

JO - Current Infectious Disease Reports

JF - Current Infectious Disease Reports

SN - 1523-3847

IS - 7

M1 - 20

ER -