Improving the performance of an acid-labile 4-hydroxymethyl phenoxyacetic acid (HMP) linker on resin and synphase(TM) grafted solid-supports

Chinh T. Bui, Francesca Ercole, Yen Pham, Rhonda Campbell, Firas A. Rasoul, Nicholas J. Ede

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

A replacement of the acetic acid moiety by valeric acid within the 4-hydroxymethylphenoxyacetic acid (HMP) linker (Sheppard RC, Williams BJ. Acid-labile resin linkage agents for use in solid phase peptide synthesis. Int. J. Peptide Protein Res. 1982; 20: 451-454) significantly improved its performance in terms of loading capacity, yield and purity of the final products. The results indicated the spacer-linker combination and type of solid supports are important factors for solid-phase synthesis. Copyright (C) 2000 European Peptide Society and John Wiley and Sons, Ltd.

Original languageEnglish
Pages (from-to)534-538
Number of pages5
JournalJournal of Peptide Science
Volume6
Issue number10
DOIs
Publication statusPublished - 13 Nov 2000
Externally publishedYes

Keywords

  • 4-Hydroxymethylphenoxyacetic acid
  • 5-(4-Hydroxymethylphenoxy)pentanoic acid
  • Multipin solid support
  • Solid phase organic chemistry

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