A replacement of the acetic acid moiety by valeric acid within the 4-hydroxymethylphenoxyacetic acid (HMP) linker (Sheppard RC, Williams BJ. Acid-labile resin linkage agents for use in solid phase peptide synthesis. Int. J. Peptide Protein Res. 1982; 20: 451-454) significantly improved its performance in terms of loading capacity, yield and purity of the final products. The results indicated the spacer-linker combination and type of solid supports are important factors for solid-phase synthesis. Copyright (C) 2000 European Peptide Society and John Wiley and Sons, Ltd.
|Number of pages||5|
|Journal||Journal of Peptide Science|
|Publication status||Published - 13 Nov 2000|
- 4-Hydroxymethylphenoxyacetic acid
- 5-(4-Hydroxymethylphenoxy)pentanoic acid
- Multipin solid support
- Solid phase organic chemistry