Improving pregnancy outcomes in humans through studies in sheep

Janna L. Morrison, Mary J. Berry, Kimberley J. Botting, Jack R.T. Darby, Martin G. Frasch, Kathryn L. Gatford, Dino A. Giussani, Clint L. Gray, Richard Harding, Emilio A. Herrera, Matthew W. Kemp, Mitchell C. Lock, I. Caroline McMillen, Timothy J. Moss, Gabrielle C. Musk, Mark H. Oliver, Timothy R.H. Regnault, Claire T. Roberts, Jia Yin Soo, Ross L. Tellam

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Experimental studies that are relevant to human pregnancy rely on the selection of appropriate animal models as an important element in experimental design. Consideration of the strengths and weaknesses of any animal model of human disease is fundamental to effective and meaningful translation of preclinical research. Studies in sheep have made significant contributions to our understanding of the normal and abnormal development of the fetus. As a model of human pregnancy, studies in sheep have enabled scientists and clinicians to answer questions about the etiology and treatment of poor maternal, placental, and fetal health and to provide an evidence base for translation of interventions to the clinic. The aim of this review is to highlight the advances in perinatal human medicine that have been achieved following translation of research using the pregnant sheep and fetus.

Original languageEnglish
Pages (from-to)R1123-R1153
Number of pages31
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume315
Issue number6
DOIs
Publication statusPublished - 1 Dec 2018

Keywords

  • Animal models
  • Fetus
  • Mother
  • Placenta
  • Pregnancy
  • Sheep

Cite this

Morrison, J. L., Berry, M. J., Botting, K. J., Darby, J. R. T., Frasch, M. G., Gatford, K. L., ... Tellam, R. L. (2018). Improving pregnancy outcomes in humans through studies in sheep. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 315(6), R1123-R1153. https://doi.org/10.1152/ajpregu.00391.2017
Morrison, Janna L. ; Berry, Mary J. ; Botting, Kimberley J. ; Darby, Jack R.T. ; Frasch, Martin G. ; Gatford, Kathryn L. ; Giussani, Dino A. ; Gray, Clint L. ; Harding, Richard ; Herrera, Emilio A. ; Kemp, Matthew W. ; Lock, Mitchell C. ; McMillen, I. Caroline ; Moss, Timothy J. ; Musk, Gabrielle C. ; Oliver, Mark H. ; Regnault, Timothy R.H. ; Roberts, Claire T. ; Soo, Jia Yin ; Tellam, Ross L. / Improving pregnancy outcomes in humans through studies in sheep. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2018 ; Vol. 315, No. 6. pp. R1123-R1153.
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abstract = "Experimental studies that are relevant to human pregnancy rely on the selection of appropriate animal models as an important element in experimental design. Consideration of the strengths and weaknesses of any animal model of human disease is fundamental to effective and meaningful translation of preclinical research. Studies in sheep have made significant contributions to our understanding of the normal and abnormal development of the fetus. As a model of human pregnancy, studies in sheep have enabled scientists and clinicians to answer questions about the etiology and treatment of poor maternal, placental, and fetal health and to provide an evidence base for translation of interventions to the clinic. The aim of this review is to highlight the advances in perinatal human medicine that have been achieved following translation of research using the pregnant sheep and fetus.",
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Morrison, JL, Berry, MJ, Botting, KJ, Darby, JRT, Frasch, MG, Gatford, KL, Giussani, DA, Gray, CL, Harding, R, Herrera, EA, Kemp, MW, Lock, MC, McMillen, IC, Moss, TJ, Musk, GC, Oliver, MH, Regnault, TRH, Roberts, CT, Soo, JY & Tellam, RL 2018, 'Improving pregnancy outcomes in humans through studies in sheep' American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 315, no. 6, pp. R1123-R1153. https://doi.org/10.1152/ajpregu.00391.2017

Improving pregnancy outcomes in humans through studies in sheep. / Morrison, Janna L.; Berry, Mary J.; Botting, Kimberley J.; Darby, Jack R.T.; Frasch, Martin G.; Gatford, Kathryn L.; Giussani, Dino A.; Gray, Clint L.; Harding, Richard; Herrera, Emilio A.; Kemp, Matthew W.; Lock, Mitchell C.; McMillen, I. Caroline; Moss, Timothy J.; Musk, Gabrielle C.; Oliver, Mark H.; Regnault, Timothy R.H.; Roberts, Claire T.; Soo, Jia Yin; Tellam, Ross L.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 315, No. 6, 01.12.2018, p. R1123-R1153.

Research output: Contribution to journalReview ArticleResearchpeer-review

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T1 - Improving pregnancy outcomes in humans through studies in sheep

AU - Morrison, Janna L.

AU - Berry, Mary J.

AU - Botting, Kimberley J.

AU - Darby, Jack R.T.

AU - Frasch, Martin G.

AU - Gatford, Kathryn L.

AU - Giussani, Dino A.

AU - Gray, Clint L.

AU - Harding, Richard

AU - Herrera, Emilio A.

AU - Kemp, Matthew W.

AU - Lock, Mitchell C.

AU - McMillen, I. Caroline

AU - Moss, Timothy J.

AU - Musk, Gabrielle C.

AU - Oliver, Mark H.

AU - Regnault, Timothy R.H.

AU - Roberts, Claire T.

AU - Soo, Jia Yin

AU - Tellam, Ross L.

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AB - Experimental studies that are relevant to human pregnancy rely on the selection of appropriate animal models as an important element in experimental design. Consideration of the strengths and weaknesses of any animal model of human disease is fundamental to effective and meaningful translation of preclinical research. Studies in sheep have made significant contributions to our understanding of the normal and abnormal development of the fetus. As a model of human pregnancy, studies in sheep have enabled scientists and clinicians to answer questions about the etiology and treatment of poor maternal, placental, and fetal health and to provide an evidence base for translation of interventions to the clinic. The aim of this review is to highlight the advances in perinatal human medicine that have been achieved following translation of research using the pregnant sheep and fetus.

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DO - 10.1152/ajpregu.00391.2017

M3 - Review Article

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SP - R1123-R1153

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