Improving oral human papillomavirus detection using toothbrush sampling in HIV-positive men who have sex with men

Jason Ong, Timothy Richard Read, Marcus Y Chen, Sandra M Walker, Matthew Law, Catriona Bradshaw, Suzanne M Garland, Sepehr N Tabrizi, Alyssa Marie Cornall, Andrew E Grulich, Jane Hocking, Christopher Kit Fairley

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Abstract

Pre- and postabrasion oral rinse samples (ORS) and a toothbrush sample detected human papillomavirus (HPV) DNA in at least one sample among 45 (26 ) of 173 HIV-positive men who have sex with men. There was moderate agreement for HPV genotype detection between the preabrasion and postabrasion ORS (? =0.49; 95 confidence interval [CI], 0.37 to 0.61). There was good agreement between postabrasion ORS and toothbrushes (? = 0.70; 95 CI, 0.60 to 0.80). The sensitivities for HPV genotypes detected were 80 (95 CI, 69 to 88) for preabrasion ORS, 65 (95 CI, 54 to 76) for postabrasion ORS, and 75 (95 CI, 63 to 84) for toothbrushes
Original languageEnglish
Pages (from-to)2206 - 2209
Number of pages4
JournalJournal of Clinical Microbiology
Volume52
Issue number6
DOIs
Publication statusPublished - 2014

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