Improving epinephrine responses in hypoglycemia unawareness with real-time continuous glucose monitoring in adolescents with type 1 diabetes

Trang Ly, Jacqueline Hewitt, Raymond J. Davey, Ee Mun Lim, Elizabeth A. Davis, Timothy W Jones

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Abstract

OBJECTIVE- To determine whether real-time continuous glucose monitoring (CGM) with preset alarms at specific glucose levels would prove a useful tool to achieve avoidance of hypoglycemia and improve the counterregulatory response to hypoglycemia in adolescents with type 1 diabetes with hypoglycemia unawareness. RESEARCH DESIGN AND METHODS- Adolescents with type 1 diabetes with hypoglycemia unawareness underwent hyperinsulinemic hypoglycemic clamp studies at baseline to determine their counterregulatory hormone responses to hypoglycemia. Subjects were then randomized to either standard therapy or real-time CGM for 4 weeks. The clamp study was then repeated. RESULTS- The epinephrine response during hypoglycemia after the intervention was greater in the CGM group than in the standard therapy group. CONCLUSIONS- A greater epinephrine response during hypoglycemia suggests that real-time CGM is a useful clinical tool to improve hypoglycemia unawareness in adolescents with type 1 diabetes.

Original languageEnglish
Pages (from-to)50-52
Number of pages3
JournalDiabetes Care
Volume34
Issue number1
DOIs
Publication statusPublished - Jan 2011
Externally publishedYes

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