Improving epinephrine responses in hypoglycemia unawareness with real-time continuous glucose monitoring in adolescents with type 1 diabetes

Trang Ly, Jacqueline Hewitt, Raymond J. Davey, Ee Mun Lim, Elizabeth A. Davis, Timothy W Jones

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Abstract

OBJECTIVE- To determine whether real-time continuous glucose monitoring (CGM) with preset alarms at specific glucose levels would prove a useful tool to achieve avoidance of hypoglycemia and improve the counterregulatory response to hypoglycemia in adolescents with type 1 diabetes with hypoglycemia unawareness. RESEARCH DESIGN AND METHODS- Adolescents with type 1 diabetes with hypoglycemia unawareness underwent hyperinsulinemic hypoglycemic clamp studies at baseline to determine their counterregulatory hormone responses to hypoglycemia. Subjects were then randomized to either standard therapy or real-time CGM for 4 weeks. The clamp study was then repeated. RESULTS- The epinephrine response during hypoglycemia after the intervention was greater in the CGM group than in the standard therapy group. CONCLUSIONS- A greater epinephrine response during hypoglycemia suggests that real-time CGM is a useful clinical tool to improve hypoglycemia unawareness in adolescents with type 1 diabetes.

Original languageEnglish
Pages (from-to)50-52
Number of pages3
JournalDiabetes Care
Volume34
Issue number1
DOIs
Publication statusPublished - Jan 2011
Externally publishedYes

Cite this

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abstract = "OBJECTIVE- To determine whether real-time continuous glucose monitoring (CGM) with preset alarms at specific glucose levels would prove a useful tool to achieve avoidance of hypoglycemia and improve the counterregulatory response to hypoglycemia in adolescents with type 1 diabetes with hypoglycemia unawareness. RESEARCH DESIGN AND METHODS- Adolescents with type 1 diabetes with hypoglycemia unawareness underwent hyperinsulinemic hypoglycemic clamp studies at baseline to determine their counterregulatory hormone responses to hypoglycemia. Subjects were then randomized to either standard therapy or real-time CGM for 4 weeks. The clamp study was then repeated. RESULTS- The epinephrine response during hypoglycemia after the intervention was greater in the CGM group than in the standard therapy group. CONCLUSIONS- A greater epinephrine response during hypoglycemia suggests that real-time CGM is a useful clinical tool to improve hypoglycemia unawareness in adolescents with type 1 diabetes.",
author = "Trang Ly and Jacqueline Hewitt and Davey, {Raymond J.} and Lim, {Ee Mun} and Davis, {Elizabeth A.} and Jones, {Timothy W}",
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Improving epinephrine responses in hypoglycemia unawareness with real-time continuous glucose monitoring in adolescents with type 1 diabetes. / Ly, Trang; Hewitt, Jacqueline; Davey, Raymond J.; Lim, Ee Mun; Davis, Elizabeth A.; Jones, Timothy W.

In: Diabetes Care, Vol. 34, No. 1, 01.2011, p. 50-52.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Improving epinephrine responses in hypoglycemia unawareness with real-time continuous glucose monitoring in adolescents with type 1 diabetes

AU - Ly, Trang

AU - Hewitt, Jacqueline

AU - Davey, Raymond J.

AU - Lim, Ee Mun

AU - Davis, Elizabeth A.

AU - Jones, Timothy W

PY - 2011/1

Y1 - 2011/1

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AB - OBJECTIVE- To determine whether real-time continuous glucose monitoring (CGM) with preset alarms at specific glucose levels would prove a useful tool to achieve avoidance of hypoglycemia and improve the counterregulatory response to hypoglycemia in adolescents with type 1 diabetes with hypoglycemia unawareness. RESEARCH DESIGN AND METHODS- Adolescents with type 1 diabetes with hypoglycemia unawareness underwent hyperinsulinemic hypoglycemic clamp studies at baseline to determine their counterregulatory hormone responses to hypoglycemia. Subjects were then randomized to either standard therapy or real-time CGM for 4 weeks. The clamp study was then repeated. RESULTS- The epinephrine response during hypoglycemia after the intervention was greater in the CGM group than in the standard therapy group. CONCLUSIONS- A greater epinephrine response during hypoglycemia suggests that real-time CGM is a useful clinical tool to improve hypoglycemia unawareness in adolescents with type 1 diabetes.

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