Improving electrospun fibre stacking with direct writing for developing scaffolds for tissue engineering for non-load bearing bone

K. A. Blackwood, N. Ristovski, S. Liao, N. Bock, J. Ren, G. Kirby, M. M. Stevens, R. Steck, M. A. Woodruff

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther

4 Citations (Scopus)

Abstract

Melt electrospinning can be used to produce fibres within the micro to nano scale with a deposition in a manner in-line with conventional 3D printing technology’s [1]. Technical issues such as charge build up in subsequent layers lead to limitations in the precision of fibre deposition as the number of layers increases. Polycaprolactone (PCL) is a polyester with a wellestablished history as a scaffold material for bone tissue engineering [2]. It is biocompatible, easy to shape and mechanically suitable for bone defects. Bioactive glasses are ceramic materials which are known to stimulate osteogenic differentiation [3]. The combination of PCL and bioactive glasses present the possibility to develop osteogenic scaffolds with a high degree of control of laydown using melt electrospinning [4]. This work develops the potential of melt electrospinning as a scaffold fabrication technique for tissue engineering non-load bearing bone defects by both developing techniques for improcing fibre laydown introducing osteogenic factors.

Original languageEnglish
Title of host publication5th International Conference on Biomedical Engineering in Vietnam
EditorsVo Van Toi, Tran Ha Lien Phuong
PublisherSpringer
Pages125-128
Number of pages4
ISBN (Electronic)9783319117751
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes
EventInternational Conference on the Development of Biomedical Engineering in Vietnam 2014 - Ho Chi Minh City, Vietnam
Duration: 16 Jun 201418 Jun 2014
Conference number: 5th

Publication series

NameIFMBE Proceedings
Volume46
ISSN (Print)1680-0737

Conference

ConferenceInternational Conference on the Development of Biomedical Engineering in Vietnam 2014
CountryVietnam
CityHo Chi Minh City
Period16/06/1418/06/14

Keywords

  • Bioactive Glass
  • Electrospinning
  • Polycaprolactone

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