TY - JOUR
T1 - Improvement of major depression is associated with increased erythrocyte DHA
AU - Meyer, Barbara
AU - Grenyer, Brin F S
AU - Crowe, Trevor
AU - Owen, Alice Jane
AU - Grigonis-Deane, Elizabeth M
AU - Howe, Peter RC
PY - 2013
Y1 - 2013
N2 - The aim of this study was to determine if changes in omega-3 polyunsaturated fatty acid status following tuna oil supplementation correlated with changes in scores of depression. A total of 95 volunteers receiving treatment for major depression were randomised to consume 8 ? 1 g capsules per day of HiDHA (2 g DHA, 0.6 g EPA and 10 mg Vitamin E) or olive oil (placebo) for 16 weeks, whilst undergoing weekly counseling sessions by trained clinical psychologists using a standard empirically validated psychotherapy. Depression status was assessed using the 17 item Hamilton rating scale for depression and the Beck Depression Inventory by a psychodiagnostician who was blind to the treatment. Blood was taken at baseline and 16 weeks (n = 48) for measurement of erythrocyte fatty acids. With HiDHA supplementation, erythrocyte DHA content rose from 4.1 ? 0.2 to 7.9 ? 0.4 (mean ? SEM, p <0.001) of total fatty acids but did not change (4.0 ? 0.2 to 4.1 ? 0.2 ) in the olive oil group. The mean changes in scores of depression did not differ significantly between the two groups (-12.2 ? 2.1 for tuna oil and -14.4 ? 2.3 for olive oil). However, analysis of covariance showed that in the fish oil group there was a significant correlation (r = -0.5n-3 Fatty acids; Nutrition1) between the change in erythrocyte DHA and the change in scores of depression (p <0.05). Further study of the relationship between DHA and depression is warranted.
AB - The aim of this study was to determine if changes in omega-3 polyunsaturated fatty acid status following tuna oil supplementation correlated with changes in scores of depression. A total of 95 volunteers receiving treatment for major depression were randomised to consume 8 ? 1 g capsules per day of HiDHA (2 g DHA, 0.6 g EPA and 10 mg Vitamin E) or olive oil (placebo) for 16 weeks, whilst undergoing weekly counseling sessions by trained clinical psychologists using a standard empirically validated psychotherapy. Depression status was assessed using the 17 item Hamilton rating scale for depression and the Beck Depression Inventory by a psychodiagnostician who was blind to the treatment. Blood was taken at baseline and 16 weeks (n = 48) for measurement of erythrocyte fatty acids. With HiDHA supplementation, erythrocyte DHA content rose from 4.1 ? 0.2 to 7.9 ? 0.4 (mean ? SEM, p <0.001) of total fatty acids but did not change (4.0 ? 0.2 to 4.1 ? 0.2 ) in the olive oil group. The mean changes in scores of depression did not differ significantly between the two groups (-12.2 ? 2.1 for tuna oil and -14.4 ? 2.3 for olive oil). However, analysis of covariance showed that in the fish oil group there was a significant correlation (r = -0.5n-3 Fatty acids; Nutrition1) between the change in erythrocyte DHA and the change in scores of depression (p <0.05). Further study of the relationship between DHA and depression is warranted.
UR - http://download.springer.com/static/pdf/915/art%253A10.1007%252Fs11745-013-3801-7.pdf?auth66=1392421121_24707fd078f59cbf0e4fcbb6cfcf23b3&ext=.pdf
U2 - 10.1007/s11745-013-3801-7
DO - 10.1007/s11745-013-3801-7
M3 - Article
SN - 0024-4201
VL - 48
SP - 863
EP - 868
JO - Lipids
JF - Lipids
IS - 9
ER -