Improved quantification of cerebral vein oxygenation using partial volume correction

Phillip G. D. Ward, Audrey P. Fan, Parnesh Raniga, David G. Barnes, David L. Dowe, Amanda C. L. Ng, Gary F. Egan

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Purpose: Quantitative susceptibility mapping (QSM) enables cerebral venous characterization and physiological measurements, such as oxygen extraction fraction (OEF). The exquisite sensitivity of QSM to deoxygenated blood makes it possible to image small veins; however partial volume effects must be addressed for accurate quantification. We present a new method, Iterative Cylindrical Fitting (ICF), to estimate voxel-based partial volume effects for susceptibility maps and use it to improve OEF quantification of small veins with diameters between 1.5 and 4 voxels.
Materials and Methods: Simulated QSM maps were generated to assess the performance of the ICF method over a range of vein geometries with varying echo times and noise levels. The ICF method was also applied to in vivo human brain data to assess the feasibility and behavior of OEF measurements compared to the maximum intensity voxel (MIV) method.

Results: Improved quantification of OEF measurements was achieved for vessels with contrast to noise greater than 3.0 and vein radii greater than 0.75 voxels. The ICF method produced improved quantitative accuracy of OEF measurement compared to the MIV approach (mean OEF error 7.7 vs. 12.4%). The ICF method provided estimates of vein radius (mean error <27%) and partial volume maps (root mean-squared error <13%). In vivo results demonstrated consistent estimates of OEF along vein segments.

Conclusion: OEF quantification in small veins (1.5–4 voxels in diameter) had lower error when using partial volume estimates from the ICF method.
LanguageEnglish
Article number89
Number of pages12
JournalFrontiers in Neuroscience
Volume11
DOIs
Publication statusPublished - 27 Feb 2017

Keywords

  • Partial volume
  • Vein
  • Oxygen extraction fraction
  • OEF
  • Quantitative susceptibility mapping
  • QSM
  • MRI

Cite this

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title = "Improved quantification of cerebral vein oxygenation using partial volume correction",
abstract = "Purpose: Quantitative susceptibility mapping (QSM) enables cerebral venous characterization and physiological measurements, such as oxygen extraction fraction (OEF). The exquisite sensitivity of QSM to deoxygenated blood makes it possible to image small veins; however partial volume effects must be addressed for accurate quantification. We present a new method, Iterative Cylindrical Fitting (ICF), to estimate voxel-based partial volume effects for susceptibility maps and use it to improve OEF quantification of small veins with diameters between 1.5 and 4 voxels.Materials and Methods: Simulated QSM maps were generated to assess the performance of the ICF method over a range of vein geometries with varying echo times and noise levels. The ICF method was also applied to in vivo human brain data to assess the feasibility and behavior of OEF measurements compared to the maximum intensity voxel (MIV) method.Results: Improved quantification of OEF measurements was achieved for vessels with contrast to noise greater than 3.0 and vein radii greater than 0.75 voxels. The ICF method produced improved quantitative accuracy of OEF measurement compared to the MIV approach (mean OEF error 7.7 vs. 12.4{\%}). The ICF method provided estimates of vein radius (mean error <27{\%}) and partial volume maps (root mean-squared error <13{\%}). In vivo results demonstrated consistent estimates of OEF along vein segments.Conclusion: OEF quantification in small veins (1.5–4 voxels in diameter) had lower error when using partial volume estimates from the ICF method.",
keywords = "Partial volume, Vein, Oxygen extraction fraction, OEF, Quantitative susceptibility mapping, QSM, MRI",
author = "Ward, {Phillip G. D.} and Fan, {Audrey P.} and Parnesh Raniga and Barnes, {David G.} and Dowe, {David L.} and Ng, {Amanda C. L.} and Egan, {Gary F.}",
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Improved quantification of cerebral vein oxygenation using partial volume correction. / Ward, Phillip G. D.; Fan, Audrey P.; Raniga, Parnesh; Barnes, David G.; Dowe, David L.; Ng, Amanda C. L.; Egan, Gary F.

In: Frontiers in Neuroscience, Vol. 11, 89, 27.02.2017.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Improved quantification of cerebral vein oxygenation using partial volume correction

AU - Ward, Phillip G. D.

AU - Fan, Audrey P.

AU - Raniga, Parnesh

AU - Barnes, David G.

AU - Dowe, David L.

AU - Ng, Amanda C. L.

AU - Egan, Gary F.

PY - 2017/2/27

Y1 - 2017/2/27

N2 - Purpose: Quantitative susceptibility mapping (QSM) enables cerebral venous characterization and physiological measurements, such as oxygen extraction fraction (OEF). The exquisite sensitivity of QSM to deoxygenated blood makes it possible to image small veins; however partial volume effects must be addressed for accurate quantification. We present a new method, Iterative Cylindrical Fitting (ICF), to estimate voxel-based partial volume effects for susceptibility maps and use it to improve OEF quantification of small veins with diameters between 1.5 and 4 voxels.Materials and Methods: Simulated QSM maps were generated to assess the performance of the ICF method over a range of vein geometries with varying echo times and noise levels. The ICF method was also applied to in vivo human brain data to assess the feasibility and behavior of OEF measurements compared to the maximum intensity voxel (MIV) method.Results: Improved quantification of OEF measurements was achieved for vessels with contrast to noise greater than 3.0 and vein radii greater than 0.75 voxels. The ICF method produced improved quantitative accuracy of OEF measurement compared to the MIV approach (mean OEF error 7.7 vs. 12.4%). The ICF method provided estimates of vein radius (mean error <27%) and partial volume maps (root mean-squared error <13%). In vivo results demonstrated consistent estimates of OEF along vein segments.Conclusion: OEF quantification in small veins (1.5–4 voxels in diameter) had lower error when using partial volume estimates from the ICF method.

AB - Purpose: Quantitative susceptibility mapping (QSM) enables cerebral venous characterization and physiological measurements, such as oxygen extraction fraction (OEF). The exquisite sensitivity of QSM to deoxygenated blood makes it possible to image small veins; however partial volume effects must be addressed for accurate quantification. We present a new method, Iterative Cylindrical Fitting (ICF), to estimate voxel-based partial volume effects for susceptibility maps and use it to improve OEF quantification of small veins with diameters between 1.5 and 4 voxels.Materials and Methods: Simulated QSM maps were generated to assess the performance of the ICF method over a range of vein geometries with varying echo times and noise levels. The ICF method was also applied to in vivo human brain data to assess the feasibility and behavior of OEF measurements compared to the maximum intensity voxel (MIV) method.Results: Improved quantification of OEF measurements was achieved for vessels with contrast to noise greater than 3.0 and vein radii greater than 0.75 voxels. The ICF method produced improved quantitative accuracy of OEF measurement compared to the MIV approach (mean OEF error 7.7 vs. 12.4%). The ICF method provided estimates of vein radius (mean error <27%) and partial volume maps (root mean-squared error <13%). In vivo results demonstrated consistent estimates of OEF along vein segments.Conclusion: OEF quantification in small veins (1.5–4 voxels in diameter) had lower error when using partial volume estimates from the ICF method.

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JO - Frontiers in Neuroscience

T2 - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

SN - 1662-453X

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