TY - JOUR
T1 - Importing mitochondrial proteins: Machineries and mechanisms
AU - Chacinska, Agnieszka
AU - Koehler, Carla M
AU - Milenkovic, Dusanka
AU - Lithgow, Trevor James
AU - Pfanner, Nikolaus
PY - 2009
Y1 - 2009
N2 - Most mitochondrial proteins are synthesized on cytosolic ribosomes and must be imported across one or both mitochondrial membranes. There is an amazingly versatile set of machineries and mechanisms, and at least four different pathways, for the importing and sorting of mitochondrial precursor proteins. The translocases that catalyze these processes are highly dynamic machines driven by the membrane potential, ATP, or redox reactions, and they cooperate with molecular chaperones and assembly complexes to direct mitochondrial proteins to their correct destinations. Here, we discuss recent insights into the importing and sorting of mitochondrial proteins and their contributions to mitochondrial biogenesis.
AB - Most mitochondrial proteins are synthesized on cytosolic ribosomes and must be imported across one or both mitochondrial membranes. There is an amazingly versatile set of machineries and mechanisms, and at least four different pathways, for the importing and sorting of mitochondrial precursor proteins. The translocases that catalyze these processes are highly dynamic machines driven by the membrane potential, ATP, or redox reactions, and they cooperate with molecular chaperones and assembly complexes to direct mitochondrial proteins to their correct destinations. Here, we discuss recent insights into the importing and sorting of mitochondrial proteins and their contributions to mitochondrial biogenesis.
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19703392
U2 - 10.1016/j.cell.2009.08.005
DO - 10.1016/j.cell.2009.08.005
M3 - Review Article
SN - 0092-8674
VL - 138
SP - 628
EP - 644
JO - Cell
JF - Cell
IS - 4
ER -