Import and assembly of proteins into mitochondria of mammalian cells

Nicholas J. Hoogenraad, Linda A. Ward, Michael T. Ryan

Research output: Contribution to journalReview ArticleResearchpeer-review

127 Citations (Scopus)

Abstract

Most of our knowledge regarding the process of protein import into mitochondria has come from research employing fungal systems. This review outlines recent advances in our understanding of this process in mammalian cells. In particular, we focus on the characterisation of cytosolic molecular chaperones that are involved in binding to mitochondrial-targeted preproteins, as well as the identification of both conserved and novel subunits of the import machineries of the outer and inner mitochondrial membranes. We also discuss diseases associated with defects in import and assembly of mitochondrial proteins and what is currently known about the regulation of import in mammals.

Original languageEnglish
Pages (from-to)97-105
Number of pages9
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1592
Issue number1
DOIs
Publication statusPublished - 2 Sep 2002
Externally publishedYes

Keywords

  • Import
  • Mitochondrion
  • Molecular chaperone
  • TIM
  • TOM

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