Implications of peptide assemblies in amyloid diseases

Pu Chun Ke, Marc Antonie Sani, Feng Ding, Aleksandr Kakinen, Ibrahim Javed, Frances Separovic, Thomas P. Davis, Raffaele Mezzenga

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the quality of life of millions worldwide, with profound social and economic implications. Despite the significant differences in pathology-much of which are poorly understood-these diseases are commonly characterized by the presence of cross-β amyloid fibrils as well as the loss of neuronal or pancreatic β-cells. In this review, we document research progress on the molecular and mesoscopic self-assembly of amyloid-beta, alpha synuclein, human islet amyloid polypeptide and prions, the peptides and proteins associated with Alzheimer's, Parkinson's, type 2 diabetes and prion diseases. In addition, we discuss the toxicities of these amyloid proteins based on their self-assembly as well as their interactions with membranes, metal ions, small molecules and engineered nanoparticles. Through this presentation we show the remarkable similarities and differences in the structural transitions of the amyloid proteins through primary and secondary nucleation, the common evolution from disordered monomers to alpha-helices and then to β-sheets when the proteins encounter the cell membrane, and, the consensus (with a few exceptions) that off-pathway oligomers, rather than amyloid fibrils, are the toxic species regardless of the pathogenic protein sequence or physicochemical properties. In addition, we highlight the crucial role of molecular self-assembly in eliciting the biological and pathological consequences of the amyloid proteins within the context of their cellular environments and their spreading between cells and organs. Exploiting such structure-function-toxicity relationship may prove pivotal for the detection and mitigation of amyloid diseases.

Original languageEnglish
Pages (from-to)6492-6531
Number of pages40
JournalChemical Society Reviews
Volume46
Issue number21
DOIs
Publication statusPublished - 7 Nov 2017

Cite this

Ke, P. C., Sani, M. A., Ding, F., Kakinen, A., Javed, I., Separovic, F., ... Mezzenga, R. (2017). Implications of peptide assemblies in amyloid diseases. Chemical Society Reviews, 46(21), 6492-6531. https://doi.org/10.1039/c7cs00372b
Ke, Pu Chun ; Sani, Marc Antonie ; Ding, Feng ; Kakinen, Aleksandr ; Javed, Ibrahim ; Separovic, Frances ; Davis, Thomas P. ; Mezzenga, Raffaele. / Implications of peptide assemblies in amyloid diseases. In: Chemical Society Reviews. 2017 ; Vol. 46, No. 21. pp. 6492-6531.
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Ke, PC, Sani, MA, Ding, F, Kakinen, A, Javed, I, Separovic, F, Davis, TP & Mezzenga, R 2017, 'Implications of peptide assemblies in amyloid diseases' Chemical Society Reviews, vol. 46, no. 21, pp. 6492-6531. https://doi.org/10.1039/c7cs00372b

Implications of peptide assemblies in amyloid diseases. / Ke, Pu Chun; Sani, Marc Antonie; Ding, Feng; Kakinen, Aleksandr; Javed, Ibrahim; Separovic, Frances; Davis, Thomas P.; Mezzenga, Raffaele.

In: Chemical Society Reviews, Vol. 46, No. 21, 07.11.2017, p. 6492-6531.

Research output: Contribution to journalReview ArticleResearchpeer-review

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