Implications of neurotrophin supported auditory neuron survival for maintenance of the tonotopic organization of the central auditory pathway

David H. Reser, Thomas R. Van De Water

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Recent experiments have demonstrated the effectiveness of members of the neurotrophin family of growth factors in supporting the survival of primary auditory neurons following ototoxic trauma. In this report, we examined the implications of these results in light of current knowledge about activity dependent central nervous system reorganization. We suggest that the use of trophic factors in conjunction with patterned stimulation of afferent nerve fibers could preserve the majority of the tonotopic arrangement of the central pathway. We propose experiments to test the effects of NT-3 induced neuron survival on the organization of primary auditory cortex.

Original languageEnglish
Pages (from-to)239-243
Number of pages5
JournalActa Oto-Laryngologica
Issue number2
Publication statusPublished - 1997
Externally publishedYes


  • central auditory system
  • cochlear implants
  • growth factor therapy
  • neural plasticity
  • neurotrophins

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