Implementing a community vector collection strategy using xenomonitoring for the endgame of lymphatic filariasis elimination

Sellase Pi-Bansa, Joseph Harold Nyarko Osei, Joannitta Joannides, Maame Esi Woode, David Agyemang, Elizabeth Elhassan, Samuel Kweku Dadzie, Maxwell Alexander Appawu, Michael David Wilson, Benjamin Guibehi Koudou, Dziedzom Komi de Souza, Jürg Utzinger, Daniel Adjei Boakye

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background
The global strategy for elimination of lymphatic filariasis is by annual mass drug administration (MDA). Effective implementation of this strategy in endemic areas reduces Wuchereria bancrofti in the blood of infected individuals to very low levels. This minimises the rate at which vectors successfully pick microfilariae from infected blood, hence requiring large mosquito numbers to detect infections. The aim of this study was to assess the feasibility of using trained community vector collectors (CVCs) to sample large mosquito numbers with minimal supervision at low cost for potential scale-up of this strategy.

Methods
CVCs and supervisors were trained in mosquito sampling methods, i.e. human landing collections, pyrethrum spray collections and window exit traps. Mosquito sampling was done over a 13-month period. Validation was conducted by a research team as quality control for mosquitoes sampled by CVCs. Data were analyzed for number of mosquitoes collected and cost incurred by the research team and CVCs during the validation phase of the study.

Results
A total of 31,064 and 8720 mosquitoes were sampled by CVCs and the research team, respectively. We found a significant difference (F(1,13) = 27.1606, P = 0.0001) in the total number of mosquitoes collected from southern and northern communities. Validation revealed similar numbers of mosquitoes sampled by CVCs and the research team, both in the wet (F(1,4) = 1.875, P = 0.309) and dry (F(1,4) = 2.276, P = 0.258) seasons in the southern communities, but was significantly different for both wet (F(1,4) = 0.022, P = 0.005) and dry (F(1,4 ) = 0.079, P = 0.033) seasons in the north. The cost of sampling mosquitoes per season was considerably lower by CVCs compared to the research team (15.170 vs 53.739 USD).

Conclusions
This study revealed the feasibility of using CVCs to sample large numbers of mosquitoes with minimal supervision from a research team at considerably lower cost than a research team for lymphatic filariasis xenomonitoring. However, evaluation of the selection and motivation of CVCs, acceptability of CVCs strategy and its epidemiological relevance for lymphatic filariasis xenomonitoring programmes need to be assessed in greater detail.
Original languageEnglish
Article number672
Number of pages10
JournalParasites and Vectors
Volume11
Issue number1
DOIs
Publication statusPublished - 27 Dec 2018
Externally publishedYes

Keywords

  • Xenomonitoring
  • Validation
  • Lymphatic filariasis
  • Wuchereria bancrofti
  • Community vector collectors

Cite this

Pi-Bansa, Sellase ; Osei, Joseph Harold Nyarko ; Joannides, Joannitta ; Woode, Maame Esi ; Agyemang, David ; Elhassan, Elizabeth ; Dadzie, Samuel Kweku ; Appawu, Maxwell Alexander ; Wilson, Michael David ; Koudou, Benjamin Guibehi ; Komi de Souza, Dziedzom ; Utzinger, Jürg ; Boakye, Daniel Adjei. / Implementing a community vector collection strategy using xenomonitoring for the endgame of lymphatic filariasis elimination. In: Parasites and Vectors. 2018 ; Vol. 11, No. 1.
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title = "Implementing a community vector collection strategy using xenomonitoring for the endgame of lymphatic filariasis elimination",
abstract = "BackgroundThe global strategy for elimination of lymphatic filariasis is by annual mass drug administration (MDA). Effective implementation of this strategy in endemic areas reduces Wuchereria bancrofti in the blood of infected individuals to very low levels. This minimises the rate at which vectors successfully pick microfilariae from infected blood, hence requiring large mosquito numbers to detect infections. The aim of this study was to assess the feasibility of using trained community vector collectors (CVCs) to sample large mosquito numbers with minimal supervision at low cost for potential scale-up of this strategy.MethodsCVCs and supervisors were trained in mosquito sampling methods, i.e. human landing collections, pyrethrum spray collections and window exit traps. Mosquito sampling was done over a 13-month period. Validation was conducted by a research team as quality control for mosquitoes sampled by CVCs. Data were analyzed for number of mosquitoes collected and cost incurred by the research team and CVCs during the validation phase of the study.ResultsA total of 31,064 and 8720 mosquitoes were sampled by CVCs and the research team, respectively. We found a significant difference (F(1,13) = 27.1606, P = 0.0001) in the total number of mosquitoes collected from southern and northern communities. Validation revealed similar numbers of mosquitoes sampled by CVCs and the research team, both in the wet (F(1,4) = 1.875, P = 0.309) and dry (F(1,4) = 2.276, P = 0.258) seasons in the southern communities, but was significantly different for both wet (F(1,4) = 0.022, P = 0.005) and dry (F(1,4 ) = 0.079, P = 0.033) seasons in the north. The cost of sampling mosquitoes per season was considerably lower by CVCs compared to the research team (15.170 vs 53.739 USD).ConclusionsThis study revealed the feasibility of using CVCs to sample large numbers of mosquitoes with minimal supervision from a research team at considerably lower cost than a research team for lymphatic filariasis xenomonitoring. However, evaluation of the selection and motivation of CVCs, acceptability of CVCs strategy and its epidemiological relevance for lymphatic filariasis xenomonitoring programmes need to be assessed in greater detail.",
keywords = "Xenomonitoring, Validation, Lymphatic filariasis, Wuchereria bancrofti, Community vector collectors",
author = "Sellase Pi-Bansa and Osei, {Joseph Harold Nyarko} and Joannitta Joannides and Woode, {Maame Esi} and David Agyemang and Elizabeth Elhassan and Dadzie, {Samuel Kweku} and Appawu, {Maxwell Alexander} and Wilson, {Michael David} and Koudou, {Benjamin Guibehi} and {Komi de Souza}, Dziedzom and J{\"u}rg Utzinger and Boakye, {Daniel Adjei}",
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journal = "Parasites and Vectors",
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Pi-Bansa, S, Osei, JHN, Joannides, J, Woode, ME, Agyemang, D, Elhassan, E, Dadzie, SK, Appawu, MA, Wilson, MD, Koudou, BG, Komi de Souza, D, Utzinger, J & Boakye, DA 2018, 'Implementing a community vector collection strategy using xenomonitoring for the endgame of lymphatic filariasis elimination', Parasites and Vectors, vol. 11, no. 1, 672. https://doi.org/10.1186/s13071-018-3260-3

Implementing a community vector collection strategy using xenomonitoring for the endgame of lymphatic filariasis elimination. / Pi-Bansa, Sellase; Osei, Joseph Harold Nyarko; Joannides, Joannitta; Woode, Maame Esi; Agyemang, David; Elhassan, Elizabeth; Dadzie, Samuel Kweku; Appawu, Maxwell Alexander; Wilson, Michael David; Koudou, Benjamin Guibehi; Komi de Souza, Dziedzom; Utzinger, Jürg; Boakye, Daniel Adjei.

In: Parasites and Vectors, Vol. 11, No. 1, 672, 27.12.2018.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Implementing a community vector collection strategy using xenomonitoring for the endgame of lymphatic filariasis elimination

AU - Pi-Bansa, Sellase

AU - Osei, Joseph Harold Nyarko

AU - Joannides, Joannitta

AU - Woode, Maame Esi

AU - Agyemang, David

AU - Elhassan, Elizabeth

AU - Dadzie, Samuel Kweku

AU - Appawu, Maxwell Alexander

AU - Wilson, Michael David

AU - Koudou, Benjamin Guibehi

AU - Komi de Souza, Dziedzom

AU - Utzinger, Jürg

AU - Boakye, Daniel Adjei

PY - 2018/12/27

Y1 - 2018/12/27

N2 - BackgroundThe global strategy for elimination of lymphatic filariasis is by annual mass drug administration (MDA). Effective implementation of this strategy in endemic areas reduces Wuchereria bancrofti in the blood of infected individuals to very low levels. This minimises the rate at which vectors successfully pick microfilariae from infected blood, hence requiring large mosquito numbers to detect infections. The aim of this study was to assess the feasibility of using trained community vector collectors (CVCs) to sample large mosquito numbers with minimal supervision at low cost for potential scale-up of this strategy.MethodsCVCs and supervisors were trained in mosquito sampling methods, i.e. human landing collections, pyrethrum spray collections and window exit traps. Mosquito sampling was done over a 13-month period. Validation was conducted by a research team as quality control for mosquitoes sampled by CVCs. Data were analyzed for number of mosquitoes collected and cost incurred by the research team and CVCs during the validation phase of the study.ResultsA total of 31,064 and 8720 mosquitoes were sampled by CVCs and the research team, respectively. We found a significant difference (F(1,13) = 27.1606, P = 0.0001) in the total number of mosquitoes collected from southern and northern communities. Validation revealed similar numbers of mosquitoes sampled by CVCs and the research team, both in the wet (F(1,4) = 1.875, P = 0.309) and dry (F(1,4) = 2.276, P = 0.258) seasons in the southern communities, but was significantly different for both wet (F(1,4) = 0.022, P = 0.005) and dry (F(1,4 ) = 0.079, P = 0.033) seasons in the north. The cost of sampling mosquitoes per season was considerably lower by CVCs compared to the research team (15.170 vs 53.739 USD).ConclusionsThis study revealed the feasibility of using CVCs to sample large numbers of mosquitoes with minimal supervision from a research team at considerably lower cost than a research team for lymphatic filariasis xenomonitoring. However, evaluation of the selection and motivation of CVCs, acceptability of CVCs strategy and its epidemiological relevance for lymphatic filariasis xenomonitoring programmes need to be assessed in greater detail.

AB - BackgroundThe global strategy for elimination of lymphatic filariasis is by annual mass drug administration (MDA). Effective implementation of this strategy in endemic areas reduces Wuchereria bancrofti in the blood of infected individuals to very low levels. This minimises the rate at which vectors successfully pick microfilariae from infected blood, hence requiring large mosquito numbers to detect infections. The aim of this study was to assess the feasibility of using trained community vector collectors (CVCs) to sample large mosquito numbers with minimal supervision at low cost for potential scale-up of this strategy.MethodsCVCs and supervisors were trained in mosquito sampling methods, i.e. human landing collections, pyrethrum spray collections and window exit traps. Mosquito sampling was done over a 13-month period. Validation was conducted by a research team as quality control for mosquitoes sampled by CVCs. Data were analyzed for number of mosquitoes collected and cost incurred by the research team and CVCs during the validation phase of the study.ResultsA total of 31,064 and 8720 mosquitoes were sampled by CVCs and the research team, respectively. We found a significant difference (F(1,13) = 27.1606, P = 0.0001) in the total number of mosquitoes collected from southern and northern communities. Validation revealed similar numbers of mosquitoes sampled by CVCs and the research team, both in the wet (F(1,4) = 1.875, P = 0.309) and dry (F(1,4) = 2.276, P = 0.258) seasons in the southern communities, but was significantly different for both wet (F(1,4) = 0.022, P = 0.005) and dry (F(1,4 ) = 0.079, P = 0.033) seasons in the north. The cost of sampling mosquitoes per season was considerably lower by CVCs compared to the research team (15.170 vs 53.739 USD).ConclusionsThis study revealed the feasibility of using CVCs to sample large numbers of mosquitoes with minimal supervision from a research team at considerably lower cost than a research team for lymphatic filariasis xenomonitoring. However, evaluation of the selection and motivation of CVCs, acceptability of CVCs strategy and its epidemiological relevance for lymphatic filariasis xenomonitoring programmes need to be assessed in greater detail.

KW - Xenomonitoring

KW - Validation

KW - Lymphatic filariasis

KW - Wuchereria bancrofti

KW - Community vector collectors

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DO - 10.1186/s13071-018-3260-3

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