Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 115 - 124 |
| Number of pages | 10 |
| Journal | Biological Psychology |
| Volume | 99 |
| DOIs | |
| Publication status | Published - 2014 |
Cite this
}
Impaired upper alpha synchronisation during working memory retention in depression and depression following traumatic brain injury. / Bailey, Neil; Segrave, Rebecca Anne; Hoy, Kate Elizabeth; Maller, Jerome Joseph; Fitzgerald, Paul Bernard.
In: Biological Psychology, Vol. 99, 2014, p. 115 - 124.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Impaired upper alpha synchronisation during working memory retention in depression and depression following traumatic brain injury
AU - Bailey, Neil
AU - Segrave, Rebecca Anne
AU - Hoy, Kate Elizabeth
AU - Maller, Jerome Joseph
AU - Fitzgerald, Paul Bernard
PY - 2014
Y1 - 2014
N2 - Rates of major depressive disorder (MDD) following traumatic brain injury (TBI) are higher than in the general population. Individuals with depression following traumatic brain injury (TBI-MDD) exhibit working memory (WM) impairments. Electrophysiological evidence has suggested that parieto-occipital upper alpha synchronisation may enhance WM retention by inhibiting irrelevant processes. The current research assessed whether retention period WM parieto-occipital upper alpha activity is disrupted in groups with TBI-only (N=20), MDD (N=17), and TBI-MDD (N=15) compared to healthy controls (N=31). Behavioural data indicated poorer performance in MDD and TBI-MDD. Parietal-occipital upper alpha was reduced in the MDD and TBI-MDD groups, but was unaffected in TBI-only. These results suggest inhibitory deficits may account for WM impairments in MDD and TBI-MDD, and that for individuals with TBI-MDD it may be the depression rather than the TBI that impairs WM.
AB - Rates of major depressive disorder (MDD) following traumatic brain injury (TBI) are higher than in the general population. Individuals with depression following traumatic brain injury (TBI-MDD) exhibit working memory (WM) impairments. Electrophysiological evidence has suggested that parieto-occipital upper alpha synchronisation may enhance WM retention by inhibiting irrelevant processes. The current research assessed whether retention period WM parieto-occipital upper alpha activity is disrupted in groups with TBI-only (N=20), MDD (N=17), and TBI-MDD (N=15) compared to healthy controls (N=31). Behavioural data indicated poorer performance in MDD and TBI-MDD. Parietal-occipital upper alpha was reduced in the MDD and TBI-MDD groups, but was unaffected in TBI-only. These results suggest inhibitory deficits may account for WM impairments in MDD and TBI-MDD, and that for individuals with TBI-MDD it may be the depression rather than the TBI that impairs WM.
UR - http://www.sciencedirect.com/science/article/pii/S0301051114000672
U2 - 10.1016/j.biopsycho.2014.03.008
DO - 10.1016/j.biopsycho.2014.03.008
M3 - Article
VL - 99
SP - 115
EP - 124
JO - Biological Psychology
JF - Biological Psychology
SN - 0301-0511
ER -