Impaired upper alpha synchronisation during working memory retention in depression and depression following traumatic brain injury

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Rates of major depressive disorder (MDD) following traumatic brain injury (TBI) are higher than in the general population. Individuals with depression following traumatic brain injury (TBI-MDD) exhibit working memory (WM) impairments. Electrophysiological evidence has suggested that parieto-occipital upper alpha synchronisation may enhance WM retention by inhibiting irrelevant processes. The current research assessed whether retention period WM parieto-occipital upper alpha activity is disrupted in groups with TBI-only (N=20), MDD (N=17), and TBI-MDD (N=15) compared to healthy controls (N=31). Behavioural data indicated poorer performance in MDD and TBI-MDD. Parietal-occipital upper alpha was reduced in the MDD and TBI-MDD groups, but was unaffected in TBI-only. These results suggest inhibitory deficits may account for WM impairments in MDD and TBI-MDD, and that for individuals with TBI-MDD it may be the depression rather than the TBI that impairs WM.
Original languageEnglish
Pages (from-to)115 - 124
Number of pages10
JournalBiological Psychology
Volume99
DOIs
Publication statusPublished - 2014

Cite this

@article{53b9082ae6cb4f5ea1c5816f2cb56e26,
title = "Impaired upper alpha synchronisation during working memory retention in depression and depression following traumatic brain injury",
abstract = "Rates of major depressive disorder (MDD) following traumatic brain injury (TBI) are higher than in the general population. Individuals with depression following traumatic brain injury (TBI-MDD) exhibit working memory (WM) impairments. Electrophysiological evidence has suggested that parieto-occipital upper alpha synchronisation may enhance WM retention by inhibiting irrelevant processes. The current research assessed whether retention period WM parieto-occipital upper alpha activity is disrupted in groups with TBI-only (N=20), MDD (N=17), and TBI-MDD (N=15) compared to healthy controls (N=31). Behavioural data indicated poorer performance in MDD and TBI-MDD. Parietal-occipital upper alpha was reduced in the MDD and TBI-MDD groups, but was unaffected in TBI-only. These results suggest inhibitory deficits may account for WM impairments in MDD and TBI-MDD, and that for individuals with TBI-MDD it may be the depression rather than the TBI that impairs WM.",
author = "Neil Bailey and Segrave, {Rebecca Anne} and Hoy, {Kate Elizabeth} and Maller, {Jerome Joseph} and Fitzgerald, {Paul Bernard}",
year = "2014",
doi = "10.1016/j.biopsycho.2014.03.008",
language = "English",
volume = "99",
pages = "115 -- 124",
journal = "Biological Psychology",
issn = "0301-0511",
publisher = "Elsevier",

}

TY - JOUR

T1 - Impaired upper alpha synchronisation during working memory retention in depression and depression following traumatic brain injury

AU - Bailey, Neil

AU - Segrave, Rebecca Anne

AU - Hoy, Kate Elizabeth

AU - Maller, Jerome Joseph

AU - Fitzgerald, Paul Bernard

PY - 2014

Y1 - 2014

N2 - Rates of major depressive disorder (MDD) following traumatic brain injury (TBI) are higher than in the general population. Individuals with depression following traumatic brain injury (TBI-MDD) exhibit working memory (WM) impairments. Electrophysiological evidence has suggested that parieto-occipital upper alpha synchronisation may enhance WM retention by inhibiting irrelevant processes. The current research assessed whether retention period WM parieto-occipital upper alpha activity is disrupted in groups with TBI-only (N=20), MDD (N=17), and TBI-MDD (N=15) compared to healthy controls (N=31). Behavioural data indicated poorer performance in MDD and TBI-MDD. Parietal-occipital upper alpha was reduced in the MDD and TBI-MDD groups, but was unaffected in TBI-only. These results suggest inhibitory deficits may account for WM impairments in MDD and TBI-MDD, and that for individuals with TBI-MDD it may be the depression rather than the TBI that impairs WM.

AB - Rates of major depressive disorder (MDD) following traumatic brain injury (TBI) are higher than in the general population. Individuals with depression following traumatic brain injury (TBI-MDD) exhibit working memory (WM) impairments. Electrophysiological evidence has suggested that parieto-occipital upper alpha synchronisation may enhance WM retention by inhibiting irrelevant processes. The current research assessed whether retention period WM parieto-occipital upper alpha activity is disrupted in groups with TBI-only (N=20), MDD (N=17), and TBI-MDD (N=15) compared to healthy controls (N=31). Behavioural data indicated poorer performance in MDD and TBI-MDD. Parietal-occipital upper alpha was reduced in the MDD and TBI-MDD groups, but was unaffected in TBI-only. These results suggest inhibitory deficits may account for WM impairments in MDD and TBI-MDD, and that for individuals with TBI-MDD it may be the depression rather than the TBI that impairs WM.

UR - http://www.sciencedirect.com/science/article/pii/S0301051114000672

U2 - 10.1016/j.biopsycho.2014.03.008

DO - 10.1016/j.biopsycho.2014.03.008

M3 - Article

VL - 99

SP - 115

EP - 124

JO - Biological Psychology

JF - Biological Psychology

SN - 0301-0511

ER -