Impaired right coronary vasodilator function in pulmonary hypertensive rats assessed by in vivo synchrotron microangiography

Tadakatsu Inagaki, Hirotsugu Tsuchimochi, James T. Pearson, Daryl O. Schwenke, Keiji Umetani, Mikiyasu Shirai, Yoshikazu Nakaoka

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review


Pulmonary hypertension (PH) causes cardiac hypertrophy in the right ventricle (RV) and eventually leads to RV failure due to persistently elevated afterload. Considerable clinical and experimental animal studies have shown that abnormalities of endothelial function represent a hallmark of heart failure. However, the relationships between right coronary endothelial dysfunction and the development of heart failure remain to be fully established especially in the right heart. Synchrotron radiation (SR) microangiography has provided the temporal and spatial resolution required to visualize microvessels of various organs in vivo [1]. Therefore, in this study, we aimed to validate a new approach for the in vivo assessment of endothelial coronary function of the rat right heart using SR microangiography.

Original languageEnglish
Title of host publicationMolecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension
EditorsToshio Nakanishi, Jeffrey R. Fineman, H. Scott Baldwin, Hiroyuki Yamagishi
Place of PublicationSingapore
PublisherSpringer-Verlag London Ltd.
Number of pages3
ISBN (Electronic)9789811511851
ISBN (Print)9789811511844
Publication statusPublished - 2020
Externally publishedYes
EventTAKAO International Symposium on Molecular Mechanism of Cardiopulmonary Disease: New Insight into the Development of Pulmonary Circulation and Ductus Arteriosus - Matsue-City of Shimane, Matsue, Japan
Duration: 6 Oct 20178 Oct 2017
Conference number: 8th


ConferenceTAKAO International Symposium on Molecular Mechanism of Cardiopulmonary Disease
Internet address


  • Coronary microangiography
  • Endothelial dysfunction
  • Right heart failure
  • Synchrotron radiation

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