Abstract
Pulmonary hypertension (PH) causes cardiac hypertrophy in the right ventricle (RV) and eventually leads to RV failure due to persistently elevated afterload. Considerable clinical and experimental animal studies have shown that abnormalities of endothelial function represent a hallmark of heart failure. However, the relationships between right coronary endothelial dysfunction and the development of heart failure remain to be fully established especially in the right heart. Synchrotron radiation (SR) microangiography has provided the temporal and spatial resolution required to visualize microvessels of various organs in vivo [1]. Therefore, in this study, we aimed to validate a new approach for the in vivo assessment of endothelial coronary function of the rat right heart using SR microangiography.
Original language | English |
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Title of host publication | Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension |
Editors | Toshio Nakanishi, Jeffrey R. Fineman, H. Scott Baldwin, Hiroyuki Yamagishi |
Place of Publication | Singapore |
Publisher | Springer-Verlag London Ltd. |
Chapter | 25 |
Pages | 193-195 |
Number of pages | 3 |
ISBN (Electronic) | 9789811511851 |
ISBN (Print) | 9789811511844 |
DOIs | |
Publication status | Published - 2020 |
Externally published | Yes |
Event | TAKAO International Symposium on Molecular Mechanism of Cardiopulmonary Disease: New Insight into the Development of Pulmonary Circulation and Ductus Arteriosus - Matsue-City of Shimane, Matsue, Japan Duration: 6 Oct 2017 → 8 Oct 2017 Conference number: 8th http://www2.convention.co.jp/takaosympo2017/greeting/ |
Conference
Conference | TAKAO International Symposium on Molecular Mechanism of Cardiopulmonary Disease |
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Country/Territory | Japan |
City | Matsue |
Period | 6/10/17 → 8/10/17 |
Internet address |
Keywords
- Coronary microangiography
- Endothelial dysfunction
- Right heart failure
- Synchrotron radiation