Impaired response inhibition is associated with self-reported symptoms of depression, anxiety, and ADHD in female FMR1 premutation carriers

Claudine Kraan, Darren Robert Hocking, Nellie Georgiou-Karistianis, Sylvia Ann Metcalfe, Alison D Archibald, Joanne Fielding, Julian Norman Trollor, John Lockyer Bradshaw, Jonathon Cohen, Kim Marie Cornish

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Fragile X Mental Retardation 1 (FMR1) premutation carriers (PM-carriers) have a defective trinucleotide expansion on the FMR1 gene that is associated with continuum of neuropsychological and mental disorders. Currently, little is known about the distinct subcomponents of executive function potentially impaired in female PM-carriers, and there have been no investigations into associations between executive function and incidences of mental disorders. A total of 35 female PM-carriers confirmed by Asuragen triple primed PCR DNA testing and 35 age- and intelligence-matched controls completed tests of executive function (i.e., response inhibition and working memory) and self-reported on social anxiety, depression, and ADHD predominantly inattentive (ADHD-PI) symptoms. Compared to controls, PM-carriers were significantly elevated on self-reported social anxiety and ADHD-PI symptoms. Irrespective of mental symptoms, female PM-carries performed significantly worse than controls on a response inhibition test, and further investigations revealed significant correlations between executive function performance and self-reported symptoms of anxiety, depression and ADHD-PI. Critically, among PM-carriers with good executive function performance, no women exceeded threshold markers for probable caseness of mental disorder. However, rates of probable caseness were elevated in those with average performance (response inhibition: social anxiety: 41.7 ; depression: 20 ; ADHD: 44.4 ; working memory: social anxiety: 27.3 ; depression: 9.1 ; ADHD: 18.2 ) and highly elevated for those with poor executive function performance (response inhibition: social anxiety: 58.3 ; depression: 80 ; ADHD: 55.6 ; working memory: social anxiety: 100 ; depression: 50 ; ADHD: 83.3 ). These data suggest that subtle executive dysfunction may be a useful neuropsychological indicator for a range of mental disorders previously reported in female PM-carriers.
Original languageEnglish
Pages (from-to)41 - 51
Number of pages11
JournalAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume165
Issue number1
DOIs
Publication statusPublished - 2014

Cite this

@article{85526c99b2bd49a193ce892f3e4a0ae9,
title = "Impaired response inhibition is associated with self-reported symptoms of depression, anxiety, and ADHD in female FMR1 premutation carriers",
abstract = "Fragile X Mental Retardation 1 (FMR1) premutation carriers (PM-carriers) have a defective trinucleotide expansion on the FMR1 gene that is associated with continuum of neuropsychological and mental disorders. Currently, little is known about the distinct subcomponents of executive function potentially impaired in female PM-carriers, and there have been no investigations into associations between executive function and incidences of mental disorders. A total of 35 female PM-carriers confirmed by Asuragen triple primed PCR DNA testing and 35 age- and intelligence-matched controls completed tests of executive function (i.e., response inhibition and working memory) and self-reported on social anxiety, depression, and ADHD predominantly inattentive (ADHD-PI) symptoms. Compared to controls, PM-carriers were significantly elevated on self-reported social anxiety and ADHD-PI symptoms. Irrespective of mental symptoms, female PM-carries performed significantly worse than controls on a response inhibition test, and further investigations revealed significant correlations between executive function performance and self-reported symptoms of anxiety, depression and ADHD-PI. Critically, among PM-carriers with good executive function performance, no women exceeded threshold markers for probable caseness of mental disorder. However, rates of probable caseness were elevated in those with average performance (response inhibition: social anxiety: 41.7 ; depression: 20 ; ADHD: 44.4 ; working memory: social anxiety: 27.3 ; depression: 9.1 ; ADHD: 18.2 ) and highly elevated for those with poor executive function performance (response inhibition: social anxiety: 58.3 ; depression: 80 ; ADHD: 55.6 ; working memory: social anxiety: 100 ; depression: 50 ; ADHD: 83.3 ). These data suggest that subtle executive dysfunction may be a useful neuropsychological indicator for a range of mental disorders previously reported in female PM-carriers.",
author = "Claudine Kraan and Hocking, {Darren Robert} and Nellie Georgiou-Karistianis and Metcalfe, {Sylvia Ann} and Archibald, {Alison D} and Joanne Fielding and Trollor, {Julian Norman} and Bradshaw, {John Lockyer} and Jonathon Cohen and Cornish, {Kim Marie}",
year = "2014",
doi = "10.1002/ajmg.b.32203",
language = "English",
volume = "165",
pages = "41 -- 51",
journal = "American Journal of Medical Genetics Part B: Neuropsychiatric Genetics",
issn = "1552-4841",
publisher = "Wiley-Blackwell",
number = "1",

}

Impaired response inhibition is associated with self-reported symptoms of depression, anxiety, and ADHD in female FMR1 premutation carriers. / Kraan, Claudine; Hocking, Darren Robert; Georgiou-Karistianis, Nellie; Metcalfe, Sylvia Ann; Archibald, Alison D; Fielding, Joanne; Trollor, Julian Norman; Bradshaw, John Lockyer; Cohen, Jonathon; Cornish, Kim Marie.

In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 165, No. 1, 2014, p. 41 - 51.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Impaired response inhibition is associated with self-reported symptoms of depression, anxiety, and ADHD in female FMR1 premutation carriers

AU - Kraan, Claudine

AU - Hocking, Darren Robert

AU - Georgiou-Karistianis, Nellie

AU - Metcalfe, Sylvia Ann

AU - Archibald, Alison D

AU - Fielding, Joanne

AU - Trollor, Julian Norman

AU - Bradshaw, John Lockyer

AU - Cohen, Jonathon

AU - Cornish, Kim Marie

PY - 2014

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N2 - Fragile X Mental Retardation 1 (FMR1) premutation carriers (PM-carriers) have a defective trinucleotide expansion on the FMR1 gene that is associated with continuum of neuropsychological and mental disorders. Currently, little is known about the distinct subcomponents of executive function potentially impaired in female PM-carriers, and there have been no investigations into associations between executive function and incidences of mental disorders. A total of 35 female PM-carriers confirmed by Asuragen triple primed PCR DNA testing and 35 age- and intelligence-matched controls completed tests of executive function (i.e., response inhibition and working memory) and self-reported on social anxiety, depression, and ADHD predominantly inattentive (ADHD-PI) symptoms. Compared to controls, PM-carriers were significantly elevated on self-reported social anxiety and ADHD-PI symptoms. Irrespective of mental symptoms, female PM-carries performed significantly worse than controls on a response inhibition test, and further investigations revealed significant correlations between executive function performance and self-reported symptoms of anxiety, depression and ADHD-PI. Critically, among PM-carriers with good executive function performance, no women exceeded threshold markers for probable caseness of mental disorder. However, rates of probable caseness were elevated in those with average performance (response inhibition: social anxiety: 41.7 ; depression: 20 ; ADHD: 44.4 ; working memory: social anxiety: 27.3 ; depression: 9.1 ; ADHD: 18.2 ) and highly elevated for those with poor executive function performance (response inhibition: social anxiety: 58.3 ; depression: 80 ; ADHD: 55.6 ; working memory: social anxiety: 100 ; depression: 50 ; ADHD: 83.3 ). These data suggest that subtle executive dysfunction may be a useful neuropsychological indicator for a range of mental disorders previously reported in female PM-carriers.

AB - Fragile X Mental Retardation 1 (FMR1) premutation carriers (PM-carriers) have a defective trinucleotide expansion on the FMR1 gene that is associated with continuum of neuropsychological and mental disorders. Currently, little is known about the distinct subcomponents of executive function potentially impaired in female PM-carriers, and there have been no investigations into associations between executive function and incidences of mental disorders. A total of 35 female PM-carriers confirmed by Asuragen triple primed PCR DNA testing and 35 age- and intelligence-matched controls completed tests of executive function (i.e., response inhibition and working memory) and self-reported on social anxiety, depression, and ADHD predominantly inattentive (ADHD-PI) symptoms. Compared to controls, PM-carriers were significantly elevated on self-reported social anxiety and ADHD-PI symptoms. Irrespective of mental symptoms, female PM-carries performed significantly worse than controls on a response inhibition test, and further investigations revealed significant correlations between executive function performance and self-reported symptoms of anxiety, depression and ADHD-PI. Critically, among PM-carriers with good executive function performance, no women exceeded threshold markers for probable caseness of mental disorder. However, rates of probable caseness were elevated in those with average performance (response inhibition: social anxiety: 41.7 ; depression: 20 ; ADHD: 44.4 ; working memory: social anxiety: 27.3 ; depression: 9.1 ; ADHD: 18.2 ) and highly elevated for those with poor executive function performance (response inhibition: social anxiety: 58.3 ; depression: 80 ; ADHD: 55.6 ; working memory: social anxiety: 100 ; depression: 50 ; ADHD: 83.3 ). These data suggest that subtle executive dysfunction may be a useful neuropsychological indicator for a range of mental disorders previously reported in female PM-carriers.

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DO - 10.1002/ajmg.b.32203

M3 - Article

VL - 165

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JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

SN - 1552-4841

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