Impaired intervertebral disc formation in the absence of Jun

Axel Behrens, Jody Haigh, Fatima Mechta-Grigoriou, Andras Nagy, Moshe Yaniv, Erwin F Wagner

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

Abstract

Jun is a major component of the heterodimeric transcription factor AP-1 and is essential for embryonic development, as foetuses that lack Jun die at mid-gestation. Ubiquitous mosaic inactivation of a conditional Jun allele by cre/LoxP-mediated recombination was used to screen for novel functions of Jun and revealed that its absence results in severe malformations of the axial skeleton. More-specific Jun deletion by collagen2a1-cre demonstrated the essential function of Jun in the notochord and sclerotome. Mutant notochordal cells showed increased apoptosis, resulting in hypocellularity of the intervertebral discs. Subsequently, fusion of vertebral bodies caused a scoliosis of the axial skeleton. Thus, Jun is required for axial skeletogenesis by regulating notochord survival and intervertebral disc formation.
Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalDevelopment
Volume130
Issue number1
DOIs
Publication statusPublished - 2003
Externally publishedYes

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