Impaired Glucocorticoid Induction of Mononuclear Leukocyte Lipocortin‐1 in Rheumatoid Arthritis

Eric F. Morand; Carolyn M. Jefferiss; Jonathan Dixey; Devashis Mitra; Nicolas J. Goulding

doi:10.1002/art.1780370209

Impaired Glucocorticoid Induction of Mononuclear Leukocyte Lipocortin‐1 in Rheumatoid Arthritis

Eric F. Morand
, Carolyn M. Jefferiss
, Jonathan Dixey
, Devashis Mitra
, Nicolas J. Goulding

Research output: Contribution to journal › Article › Research › peer-review

33 Citations (Scopus)

Abstract

Objective. To investigate leukocyte lipocortin‐1 production in rheumatoid arthritis (RA). Methods. Eight control and 8 RA subjects received 100 mg hydrocortisone intravenously. Leukocyte lipocortin‐1 was measured by enzyme‐linked immunosorbent assay. Results. Hydrocortisone induced significant increases in lipocortin‐1 production by control mononuclear cells (MNC) (P = 0.006 versus baseline) but not by RA MNC (P = 0.44 versus baseline). Peak lipocortin‐1 levels in control MNC were significantly higher than those in RA MNC (P = 0.014). Conclusion. These results indicate that glucocorticoid‐induced MNC lipocortin‐1 production is impaired in RA.

Original language	English
Pages (from-to)	207-211
Number of pages	5
Journal	Arthritis and Rheumatism
Volume	37
Issue number	2
DOIs	https://doi.org/10.1002/art.1780370209
Publication status	Published - 1 Jan 1994
Externally published	Yes

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title = "Impaired Glucocorticoid Induction of Mononuclear Leukocyte Lipocortin‐1 in Rheumatoid Arthritis",

abstract = "Objective. To investigate leukocyte lipocortin‐1 production in rheumatoid arthritis (RA). Methods. Eight control and 8 RA subjects received 100 mg hydrocortisone intravenously. Leukocyte lipocortin‐1 was measured by enzyme‐linked immunosorbent assay. Results. Hydrocortisone induced significant increases in lipocortin‐1 production by control mononuclear cells (MNC) (P = 0.006 versus baseline) but not by RA MNC (P = 0.44 versus baseline). Peak lipocortin‐1 levels in control MNC were significantly higher than those in RA MNC (P = 0.014). Conclusion. These results indicate that glucocorticoid‐induced MNC lipocortin‐1 production is impaired in RA.",

author = "Morand, \{Eric F.\} and Jefferiss, \{Carolyn M.\} and Jonathan Dixey and Devashis Mitra and Goulding, \{Nicolas J.\}",

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doi = "10.1002/art.1780370209",

language = "English",

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pages = "207--211",

journal = "Arthritis and Rheumatism",

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TY - JOUR

T1 - Impaired Glucocorticoid Induction of Mononuclear Leukocyte Lipocortin‐1 in Rheumatoid Arthritis

AU - Morand, Eric F.

AU - Jefferiss, Carolyn M.

AU - Dixey, Jonathan

AU - Mitra, Devashis

AU - Goulding, Nicolas J.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Objective. To investigate leukocyte lipocortin‐1 production in rheumatoid arthritis (RA). Methods. Eight control and 8 RA subjects received 100 mg hydrocortisone intravenously. Leukocyte lipocortin‐1 was measured by enzyme‐linked immunosorbent assay. Results. Hydrocortisone induced significant increases in lipocortin‐1 production by control mononuclear cells (MNC) (P = 0.006 versus baseline) but not by RA MNC (P = 0.44 versus baseline). Peak lipocortin‐1 levels in control MNC were significantly higher than those in RA MNC (P = 0.014). Conclusion. These results indicate that glucocorticoid‐induced MNC lipocortin‐1 production is impaired in RA.

AB - Objective. To investigate leukocyte lipocortin‐1 production in rheumatoid arthritis (RA). Methods. Eight control and 8 RA subjects received 100 mg hydrocortisone intravenously. Leukocyte lipocortin‐1 was measured by enzyme‐linked immunosorbent assay. Results. Hydrocortisone induced significant increases in lipocortin‐1 production by control mononuclear cells (MNC) (P = 0.006 versus baseline) but not by RA MNC (P = 0.44 versus baseline). Peak lipocortin‐1 levels in control MNC were significantly higher than those in RA MNC (P = 0.014). Conclusion. These results indicate that glucocorticoid‐induced MNC lipocortin‐1 production is impaired in RA.

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DO - 10.1002/art.1780370209

M3 - Article

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AN - SCOPUS:0027957768

SN - 0004-3591

VL - 37

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JO - Arthritis and Rheumatism

JF - Arthritis and Rheumatism

IS - 2

ER -

Impaired Glucocorticoid Induction of Mononuclear Leukocyte Lipocortin‐1 in Rheumatoid Arthritis

Abstract

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