Impaired Glucocorticoid Induction of Mononuclear Leukocyte Lipocortin‐1 in Rheumatoid Arthritis

Eric F. Morand, Carolyn M. Jefferiss, Jonathan Dixey, Devashis Mitra, Nicolas J. Goulding

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Objective. To investigate leukocyte lipocortin‐1 production in rheumatoid arthritis (RA). Methods. Eight control and 8 RA subjects received 100 mg hydrocortisone intravenously. Leukocyte lipocortin‐1 was measured by enzyme‐linked immunosorbent assay. Results. Hydrocortisone induced significant increases in lipocortin‐1 production by control mononuclear cells (MNC) (P = 0.006 versus baseline) but not by RA MNC (P = 0.44 versus baseline). Peak lipocortin‐1 levels in control MNC were significantly higher than those in RA MNC (P = 0.014). Conclusion. These results indicate that glucocorticoid‐induced MNC lipocortin‐1 production is impaired in RA.

Original languageEnglish
Pages (from-to)207-211
Number of pages5
JournalArthritis and Rheumatism
Issue number2
Publication statusPublished - 1 Jan 1994
Externally publishedYes

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