TY - JOUR
T1 - Impact of uricosurics on mortality outcomes in patients with COVID-19
T2 - a systematic review and meta-analysis of randomized controlled trials
AU - Kow, Chia Siang
AU - Ramachandram, Dinesh Sangarran
AU - Hasan, Syed Shahzad
AU - Thiruchelvam, Kaeshaelya
N1 - Publisher Copyright:
© 2024 The Author(s). Published by Oxford University Press on behalf of the Royal Pharmaceutical Society.
PY - 2024/6
Y1 - 2024/6
N2 - Objectives: To determine risks associated with uricosurics in COVID-19 patients. Methods: A systematic review and meta-analysis was conducted by systematically searching electronic databases. Key findings: The pooled analysis of the included trials revealed that the use of uricosurics was not associated with the risk of mortality (pooled odds ratio [OR] = 1.03, 95% confidence interval [CI]: 0.94-1.12). However, there is a potential mortality benefit associated with the use of ascorbic acid (pooled OR = 0.78, 95% CI: 0.65-0.94). Conclusions: The findings confirmed the safety of uricosurics in COVID-19 patients, despite their potential to cause uric acid excretion, which may possess antioxidant properties.
AB - Objectives: To determine risks associated with uricosurics in COVID-19 patients. Methods: A systematic review and meta-analysis was conducted by systematically searching electronic databases. Key findings: The pooled analysis of the included trials revealed that the use of uricosurics was not associated with the risk of mortality (pooled odds ratio [OR] = 1.03, 95% confidence interval [CI]: 0.94-1.12). However, there is a potential mortality benefit associated with the use of ascorbic acid (pooled OR = 0.78, 95% CI: 0.65-0.94). Conclusions: The findings confirmed the safety of uricosurics in COVID-19 patients, despite their potential to cause uric acid excretion, which may possess antioxidant properties.
KW - COVID-19
KW - mortality
KW - uricosuric
UR - https://www.scopus.com/pages/publications/85192420347
U2 - 10.1093/ijpp/riae003
DO - 10.1093/ijpp/riae003
M3 - Article
C2 - 38438314
AN - SCOPUS:85192420347
SN - 0961-7671
VL - 32
SP - 259
EP - 264
JO - International Journal of Pharmacy Practice
JF - International Journal of Pharmacy Practice
IS - 3
ER -