Impact of the HYPITAT trial on doctors' behaviour and prevalence of eclampsia in the Netherlands

K. Van Der Tuuk, C. M. Koopmans, H. Groen, B. W. Mol, M. G. Van Pampus, for the HYPITAT study group

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We questioned if participation in the HYPITAT trial (induction of labour versus expectant monitoring in women with gestational hypertension or pre-eclampsia at term) impacted implementation of its results and subsequently maternal health. We identified women with hypertensive disease from the Perinatal Registry, and distinguished the period before, during and after the trial. We included 43 641 women. Induction of labour increased from 58.3 to 67.1% (P < 0.001) and prevalence of eclampsia decreased from 0.85 to 0.19% (P < 0.001) before and after the trial. Concurrently, participation in the HYPITAT trial among others had immediate consequences for obstetric management and maternal health.

Original languageEnglish
Pages (from-to)1658-1660
Number of pages3
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Issue number13
Publication statusPublished - 1 Dec 2011
Externally publishedYes


  • Eclampsia
  • hypertension
  • induction of labour
  • preeclampsia
  • pregnancy

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