Impact of statins on serial coronary calcification during atheroma progression and regression

Rishi Puri, Stephen J. Nicholls, Mingyuan Shao, Yu Kataoka, Kiyoko Uno, Samir R. Kapadia, E. Murat Tuzcu, Steven E. Nissen

Research output: Contribution to journalArticleResearchpeer-review

200 Citations (Scopus)

Abstract

BACKGROUND Statins can regress coronary atheroma and lower clinical events. Although pre-clinical studies suggest procalcific effects of statins in vitro, it remains unclear if statins can modulate coronary atheroma calcification in vivo. OBJECTIVES This study compared changes in coronary atheroma volume and calcium indices (CaI) in patients receiving high-intensity statin therapy (HIST), low-intensity statin therapy (LIST), and no-statin therapy. METHODS In a post-hoc patient-level analysis of 8 prospective randomized trials using serial coronary intravascular ultrasound, serial changes in coronary percent atheroma volume (PAV) and CaI were measured across matched coronary segments in patients with coronary artery disease. RESULTS Following propensity-weighted adjustment for differences in baseline and changes in clinical, laboratory, and ultrasonic characteristics, HIST (n = 1,545) associated with PAV regression from baseline (-0.6 ± 0.1%; p < 0.001), whereas both LIST (n = 1,726) and no-statin therapy (n = 224) associated with PAV progression (0.8 ± 0.1% and 1.0 ± 0.1%; p < 0.001, respectively; p < 0.001 for both HIST vs. LIST and HIST vs. no-statin; p = 0.35 for LIST vs. no-statin). Significant increases in CaI from baseline were noted across all groups (median [interquartile range] HIST, 0.044 [0.0-0.12]; LIST, 0.038 [0.0-0.11]; no-statin, 0.020 [0.0-0.10]; p < 0.001 for all), which could relate to statin intensity (p = 0.03 for LIST vs. no-statin; p = 0.007 for HIST vs. no-statin; p = 0.18 for HIST vs. LIST). No correlations were found between changes in CaI and on-treatment levels of atherogenic and antiatherogenic lipoproteins, and C-reactive protein, in either of the HIST groups or the no-statin group. CONCLUSIONS Independent of their plaque-regressive effects, statins promote coronary atheroma calcification. These findings provide insight as to how statins may stabilize plaque beyond their effects on plaque regression.

Original languageEnglish
Pages (from-to)1273-1282
Number of pages10
JournalJournal of the American College of Cardiology
Volume65
Issue number13
DOIs
Publication statusPublished - 1 Jan 2015
Externally publishedYes

Keywords

  • Atherosclerosis
  • Calcium
  • Intravascular ultrasound
  • Statins

Cite this

Puri, Rishi ; Nicholls, Stephen J. ; Shao, Mingyuan ; Kataoka, Yu ; Uno, Kiyoko ; Kapadia, Samir R. ; Tuzcu, E. Murat ; Nissen, Steven E. / Impact of statins on serial coronary calcification during atheroma progression and regression. In: Journal of the American College of Cardiology. 2015 ; Vol. 65, No. 13. pp. 1273-1282.
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title = "Impact of statins on serial coronary calcification during atheroma progression and regression",
abstract = "BACKGROUND Statins can regress coronary atheroma and lower clinical events. Although pre-clinical studies suggest procalcific effects of statins in vitro, it remains unclear if statins can modulate coronary atheroma calcification in vivo. OBJECTIVES This study compared changes in coronary atheroma volume and calcium indices (CaI) in patients receiving high-intensity statin therapy (HIST), low-intensity statin therapy (LIST), and no-statin therapy. METHODS In a post-hoc patient-level analysis of 8 prospective randomized trials using serial coronary intravascular ultrasound, serial changes in coronary percent atheroma volume (PAV) and CaI were measured across matched coronary segments in patients with coronary artery disease. RESULTS Following propensity-weighted adjustment for differences in baseline and changes in clinical, laboratory, and ultrasonic characteristics, HIST (n = 1,545) associated with PAV regression from baseline (-0.6 ± 0.1{\%}; p < 0.001), whereas both LIST (n = 1,726) and no-statin therapy (n = 224) associated with PAV progression (0.8 ± 0.1{\%} and 1.0 ± 0.1{\%}; p < 0.001, respectively; p < 0.001 for both HIST vs. LIST and HIST vs. no-statin; p = 0.35 for LIST vs. no-statin). Significant increases in CaI from baseline were noted across all groups (median [interquartile range] HIST, 0.044 [0.0-0.12]; LIST, 0.038 [0.0-0.11]; no-statin, 0.020 [0.0-0.10]; p < 0.001 for all), which could relate to statin intensity (p = 0.03 for LIST vs. no-statin; p = 0.007 for HIST vs. no-statin; p = 0.18 for HIST vs. LIST). No correlations were found between changes in CaI and on-treatment levels of atherogenic and antiatherogenic lipoproteins, and C-reactive protein, in either of the HIST groups or the no-statin group. CONCLUSIONS Independent of their plaque-regressive effects, statins promote coronary atheroma calcification. These findings provide insight as to how statins may stabilize plaque beyond their effects on plaque regression.",
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Impact of statins on serial coronary calcification during atheroma progression and regression. / Puri, Rishi; Nicholls, Stephen J.; Shao, Mingyuan; Kataoka, Yu; Uno, Kiyoko; Kapadia, Samir R.; Tuzcu, E. Murat; Nissen, Steven E.

In: Journal of the American College of Cardiology, Vol. 65, No. 13, 01.01.2015, p. 1273-1282.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Impact of statins on serial coronary calcification during atheroma progression and regression

AU - Puri, Rishi

AU - Nicholls, Stephen J.

AU - Shao, Mingyuan

AU - Kataoka, Yu

AU - Uno, Kiyoko

AU - Kapadia, Samir R.

AU - Tuzcu, E. Murat

AU - Nissen, Steven E.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - BACKGROUND Statins can regress coronary atheroma and lower clinical events. Although pre-clinical studies suggest procalcific effects of statins in vitro, it remains unclear if statins can modulate coronary atheroma calcification in vivo. OBJECTIVES This study compared changes in coronary atheroma volume and calcium indices (CaI) in patients receiving high-intensity statin therapy (HIST), low-intensity statin therapy (LIST), and no-statin therapy. METHODS In a post-hoc patient-level analysis of 8 prospective randomized trials using serial coronary intravascular ultrasound, serial changes in coronary percent atheroma volume (PAV) and CaI were measured across matched coronary segments in patients with coronary artery disease. RESULTS Following propensity-weighted adjustment for differences in baseline and changes in clinical, laboratory, and ultrasonic characteristics, HIST (n = 1,545) associated with PAV regression from baseline (-0.6 ± 0.1%; p < 0.001), whereas both LIST (n = 1,726) and no-statin therapy (n = 224) associated with PAV progression (0.8 ± 0.1% and 1.0 ± 0.1%; p < 0.001, respectively; p < 0.001 for both HIST vs. LIST and HIST vs. no-statin; p = 0.35 for LIST vs. no-statin). Significant increases in CaI from baseline were noted across all groups (median [interquartile range] HIST, 0.044 [0.0-0.12]; LIST, 0.038 [0.0-0.11]; no-statin, 0.020 [0.0-0.10]; p < 0.001 for all), which could relate to statin intensity (p = 0.03 for LIST vs. no-statin; p = 0.007 for HIST vs. no-statin; p = 0.18 for HIST vs. LIST). No correlations were found between changes in CaI and on-treatment levels of atherogenic and antiatherogenic lipoproteins, and C-reactive protein, in either of the HIST groups or the no-statin group. CONCLUSIONS Independent of their plaque-regressive effects, statins promote coronary atheroma calcification. These findings provide insight as to how statins may stabilize plaque beyond their effects on plaque regression.

AB - BACKGROUND Statins can regress coronary atheroma and lower clinical events. Although pre-clinical studies suggest procalcific effects of statins in vitro, it remains unclear if statins can modulate coronary atheroma calcification in vivo. OBJECTIVES This study compared changes in coronary atheroma volume and calcium indices (CaI) in patients receiving high-intensity statin therapy (HIST), low-intensity statin therapy (LIST), and no-statin therapy. METHODS In a post-hoc patient-level analysis of 8 prospective randomized trials using serial coronary intravascular ultrasound, serial changes in coronary percent atheroma volume (PAV) and CaI were measured across matched coronary segments in patients with coronary artery disease. RESULTS Following propensity-weighted adjustment for differences in baseline and changes in clinical, laboratory, and ultrasonic characteristics, HIST (n = 1,545) associated with PAV regression from baseline (-0.6 ± 0.1%; p < 0.001), whereas both LIST (n = 1,726) and no-statin therapy (n = 224) associated with PAV progression (0.8 ± 0.1% and 1.0 ± 0.1%; p < 0.001, respectively; p < 0.001 for both HIST vs. LIST and HIST vs. no-statin; p = 0.35 for LIST vs. no-statin). Significant increases in CaI from baseline were noted across all groups (median [interquartile range] HIST, 0.044 [0.0-0.12]; LIST, 0.038 [0.0-0.11]; no-statin, 0.020 [0.0-0.10]; p < 0.001 for all), which could relate to statin intensity (p = 0.03 for LIST vs. no-statin; p = 0.007 for HIST vs. no-statin; p = 0.18 for HIST vs. LIST). No correlations were found between changes in CaI and on-treatment levels of atherogenic and antiatherogenic lipoproteins, and C-reactive protein, in either of the HIST groups or the no-statin group. CONCLUSIONS Independent of their plaque-regressive effects, statins promote coronary atheroma calcification. These findings provide insight as to how statins may stabilize plaque beyond their effects on plaque regression.

KW - Atherosclerosis

KW - Calcium

KW - Intravascular ultrasound

KW - Statins

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DO - 10.1016/j.jacc.2015.01.036

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JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

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