Impact of sex and age on the performance of FINDRISC: The HUNT study in Norway

Anne Jølle, Kristian Midthjell, Jostein Holmen, Jaakko Tuomilehto, Sven M. Carlsen, Jonathan Shaw, Bjørn O. Åsvold

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective: The Finnish Diabetes Risk Score (FINDRISC) is recommended as a screening tool for diabetes risk. However, there is a lack of well-powered studies examining the performance of FINDRISC by sex and age. We aim to estimate, by sex and age, the prevalence of elevated FINDRISC and positive predictive value (PPV) of FINDRISC for identifying impaired glucose metabolism (IGM) in a general Norwegian population. Research design and methods: We estimated the prevalence of elevated FINDRISC (≥15) among 47 694 adults in the third survey of the Nord-Trøndelag Health Study (HUNT3, 2006–08). Among 2559 participants who participated in oral glucose tolerance testing, we estimated the PPV of elevated FINDRISC for identifying unknown prevalent diabetes and other forms of IGM. Results: The prevalence of elevated FINDRISC was 12.1% in women, 9.6% in men, and increased from 1.5% at age 20–39 to 25.1% at age 70–79 years. The PPVs of elevated FINDRISC were 9.8% for diabetes, 16.9% for impaired glucose tolerance, 8.2% for impaired fasting glucose, and 34.9% for any form of IGM. The PPV for IGM was lower in women (31.2%) than in men (40.4%), and increased from 19.1% at age 20–39 to 55.5% at age ≥80 years. Conclusions: FINDRISC identified more women than men as high-risk individuals for diabetes. FINDRISC had a high PPV for detecting prevalent IGM, and the PPV was higher in men than in women and in the older individuals. Our data indicate that the impact of sex and age on diabetes risk is not fully captured by FINDRISC, and that refinements to it might improve diabetes prediction.

Original languageEnglish
Article numbere000217
JournalBMJ Open Diabetes Research & Care
Volume4
Issue number1
DOIs
Publication statusPublished - 1 Jun 2016
Externally publishedYes

Cite this

Jølle, A., Midthjell, K., Holmen, J., Tuomilehto, J., Carlsen, S. M., Shaw, J., & Åsvold, B. O. (2016). Impact of sex and age on the performance of FINDRISC: The HUNT study in Norway. BMJ Open Diabetes Research & Care, 4(1), [e000217]. https://doi.org/10.1136/bmjdrc-2016-000217
Jølle, Anne ; Midthjell, Kristian ; Holmen, Jostein ; Tuomilehto, Jaakko ; Carlsen, Sven M. ; Shaw, Jonathan ; Åsvold, Bjørn O. / Impact of sex and age on the performance of FINDRISC : The HUNT study in Norway. In: BMJ Open Diabetes Research & Care. 2016 ; Vol. 4, No. 1.
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title = "Impact of sex and age on the performance of FINDRISC: The HUNT study in Norway",
abstract = "Objective: The Finnish Diabetes Risk Score (FINDRISC) is recommended as a screening tool for diabetes risk. However, there is a lack of well-powered studies examining the performance of FINDRISC by sex and age. We aim to estimate, by sex and age, the prevalence of elevated FINDRISC and positive predictive value (PPV) of FINDRISC for identifying impaired glucose metabolism (IGM) in a general Norwegian population. Research design and methods: We estimated the prevalence of elevated FINDRISC (≥15) among 47 694 adults in the third survey of the Nord-Tr{\o}ndelag Health Study (HUNT3, 2006–08). Among 2559 participants who participated in oral glucose tolerance testing, we estimated the PPV of elevated FINDRISC for identifying unknown prevalent diabetes and other forms of IGM. Results: The prevalence of elevated FINDRISC was 12.1{\%} in women, 9.6{\%} in men, and increased from 1.5{\%} at age 20–39 to 25.1{\%} at age 70–79 years. The PPVs of elevated FINDRISC were 9.8{\%} for diabetes, 16.9{\%} for impaired glucose tolerance, 8.2{\%} for impaired fasting glucose, and 34.9{\%} for any form of IGM. The PPV for IGM was lower in women (31.2{\%}) than in men (40.4{\%}), and increased from 19.1{\%} at age 20–39 to 55.5{\%} at age ≥80 years. Conclusions: FINDRISC identified more women than men as high-risk individuals for diabetes. FINDRISC had a high PPV for detecting prevalent IGM, and the PPV was higher in men than in women and in the older individuals. Our data indicate that the impact of sex and age on diabetes risk is not fully captured by FINDRISC, and that refinements to it might improve diabetes prediction.",
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Jølle, A, Midthjell, K, Holmen, J, Tuomilehto, J, Carlsen, SM, Shaw, J & Åsvold, BO 2016, 'Impact of sex and age on the performance of FINDRISC: The HUNT study in Norway' BMJ Open Diabetes Research & Care, vol. 4, no. 1, e000217. https://doi.org/10.1136/bmjdrc-2016-000217

Impact of sex and age on the performance of FINDRISC : The HUNT study in Norway. / Jølle, Anne; Midthjell, Kristian; Holmen, Jostein; Tuomilehto, Jaakko; Carlsen, Sven M.; Shaw, Jonathan; Åsvold, Bjørn O.

In: BMJ Open Diabetes Research & Care, Vol. 4, No. 1, e000217, 01.06.2016.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Impact of sex and age on the performance of FINDRISC

T2 - The HUNT study in Norway

AU - Jølle, Anne

AU - Midthjell, Kristian

AU - Holmen, Jostein

AU - Tuomilehto, Jaakko

AU - Carlsen, Sven M.

AU - Shaw, Jonathan

AU - Åsvold, Bjørn O.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Objective: The Finnish Diabetes Risk Score (FINDRISC) is recommended as a screening tool for diabetes risk. However, there is a lack of well-powered studies examining the performance of FINDRISC by sex and age. We aim to estimate, by sex and age, the prevalence of elevated FINDRISC and positive predictive value (PPV) of FINDRISC for identifying impaired glucose metabolism (IGM) in a general Norwegian population. Research design and methods: We estimated the prevalence of elevated FINDRISC (≥15) among 47 694 adults in the third survey of the Nord-Trøndelag Health Study (HUNT3, 2006–08). Among 2559 participants who participated in oral glucose tolerance testing, we estimated the PPV of elevated FINDRISC for identifying unknown prevalent diabetes and other forms of IGM. Results: The prevalence of elevated FINDRISC was 12.1% in women, 9.6% in men, and increased from 1.5% at age 20–39 to 25.1% at age 70–79 years. The PPVs of elevated FINDRISC were 9.8% for diabetes, 16.9% for impaired glucose tolerance, 8.2% for impaired fasting glucose, and 34.9% for any form of IGM. The PPV for IGM was lower in women (31.2%) than in men (40.4%), and increased from 19.1% at age 20–39 to 55.5% at age ≥80 years. Conclusions: FINDRISC identified more women than men as high-risk individuals for diabetes. FINDRISC had a high PPV for detecting prevalent IGM, and the PPV was higher in men than in women and in the older individuals. Our data indicate that the impact of sex and age on diabetes risk is not fully captured by FINDRISC, and that refinements to it might improve diabetes prediction.

AB - Objective: The Finnish Diabetes Risk Score (FINDRISC) is recommended as a screening tool for diabetes risk. However, there is a lack of well-powered studies examining the performance of FINDRISC by sex and age. We aim to estimate, by sex and age, the prevalence of elevated FINDRISC and positive predictive value (PPV) of FINDRISC for identifying impaired glucose metabolism (IGM) in a general Norwegian population. Research design and methods: We estimated the prevalence of elevated FINDRISC (≥15) among 47 694 adults in the third survey of the Nord-Trøndelag Health Study (HUNT3, 2006–08). Among 2559 participants who participated in oral glucose tolerance testing, we estimated the PPV of elevated FINDRISC for identifying unknown prevalent diabetes and other forms of IGM. Results: The prevalence of elevated FINDRISC was 12.1% in women, 9.6% in men, and increased from 1.5% at age 20–39 to 25.1% at age 70–79 years. The PPVs of elevated FINDRISC were 9.8% for diabetes, 16.9% for impaired glucose tolerance, 8.2% for impaired fasting glucose, and 34.9% for any form of IGM. The PPV for IGM was lower in women (31.2%) than in men (40.4%), and increased from 19.1% at age 20–39 to 55.5% at age ≥80 years. Conclusions: FINDRISC identified more women than men as high-risk individuals for diabetes. FINDRISC had a high PPV for detecting prevalent IGM, and the PPV was higher in men than in women and in the older individuals. Our data indicate that the impact of sex and age on diabetes risk is not fully captured by FINDRISC, and that refinements to it might improve diabetes prediction.

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U2 - 10.1136/bmjdrc-2016-000217

DO - 10.1136/bmjdrc-2016-000217

M3 - Article

VL - 4

JO - BMJ Open Diabetes Research & Care

JF - BMJ Open Diabetes Research & Care

SN - 2052-4897

IS - 1

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