Abstract
PEG-functionalized nanoparticles as carriers of chemotherapeutics agents have been explored with notable successes in preclinical and clinical stages of cancer treatment, with some already approved by FDA, namely PEGylated liposomes and polymers. Half-life extension of therapeutic agents through PEGylation process improves their pharmacokinetic (PK) profiles, thereby reducing their dosing frequency. Protein corona composition of PEGylated nanoparticles (NPs) confers a tremendous influence on their surface characteristics which directly impact tumor accumulation and clearance properties of the drugs. By controlling the size and complexity of PEG molecules, as well as by attaching targeting moieties, the surface characteristics of NPs can be manipulated to improve their tumor uptake without sacrificing the circulation time. This review focuses on design and applications of PEGylated NPs for tumor targeted drug delivery in animal models and clinical setting.
| Original language | English |
|---|---|
| Pages (from-to) | 3283-3296 |
| Number of pages | 14 |
| Journal | Current Pharmaceutical Design |
| Volume | 24 |
| Issue number | 28 |
| DOIs | |
| Publication status | Published - 30 Jul 2018 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Biodistribution
- Nanoparticles
- PEGylation
- Pharmacokinetics
- Protein corona
- Tumor accumulation
- Tumor regression
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