Impact of intrauterine growth restriction on preterm lung disease

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Aim Intrauterine growth restriction (IUGR) is an important cause for prematurity and adversely influences prematurity-related morbidities. This study evaluates the impact of IUGR on respiratory outcomes in infants <32 weeks with IUGR and birthweight <10th centile (SGA) compared to matched appropriate for gestation (AGA) controls. Methods The primary outcomes of this retrospective study are short-term pulmonary outcomes of chronic lung disease (CLD), CLD or death, and need for home oxygen at discharge. Subgroup analysis by gestation-based stratification (<28 and ≥28 <32 weeks) was decided a priori. Results Total of 153 IUGR and 306 non-IUGR infants were enrolled. The rate of CLD (45% vs. 17%, p = 0.0001), death (16% vs. 4.6%, p = 0.0001), CLD or death (46% vs. 21.5%, p = 0.0001), home oxygen rates (13.7% vs. 6.5%, p = 0.01) and duration of respiratory support was significantly higher in the IUGR group. IUGR emerged as the strongest predictor of CLD (adjusted OR, 95%CI: (8.4 [2, 35]) and CLD or death (12.7 [3, 54]) across all gestation. Conclusion IUGR is a major risk factor for adverse short-term pulmonary outcomes as reflected by higher rates of CLD, CLD or death, and oxygen dependency at discharge in preterm infants.

Original languageEnglish
Pages (from-to)e552 - e556
Number of pages5
JournalActa Paediatrica
Volume104
Issue number12
DOIs
Publication statusPublished - 1 Dec 2015

Keywords

  • Chronic lung disease
  • Intrauterine growth restriction
  • Prematurity

Cite this

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title = "Impact of intrauterine growth restriction on preterm lung disease",
abstract = "Aim Intrauterine growth restriction (IUGR) is an important cause for prematurity and adversely influences prematurity-related morbidities. This study evaluates the impact of IUGR on respiratory outcomes in infants <32 weeks with IUGR and birthweight <10th centile (SGA) compared to matched appropriate for gestation (AGA) controls. Methods The primary outcomes of this retrospective study are short-term pulmonary outcomes of chronic lung disease (CLD), CLD or death, and need for home oxygen at discharge. Subgroup analysis by gestation-based stratification (<28 and ≥28 <32 weeks) was decided a priori. Results Total of 153 IUGR and 306 non-IUGR infants were enrolled. The rate of CLD (45{\%} vs. 17{\%}, p = 0.0001), death (16{\%} vs. 4.6{\%}, p = 0.0001), CLD or death (46{\%} vs. 21.5{\%}, p = 0.0001), home oxygen rates (13.7{\%} vs. 6.5{\%}, p = 0.01) and duration of respiratory support was significantly higher in the IUGR group. IUGR emerged as the strongest predictor of CLD (adjusted OR, 95{\%}CI: (8.4 [2, 35]) and CLD or death (12.7 [3, 54]) across all gestation. Conclusion IUGR is a major risk factor for adverse short-term pulmonary outcomes as reflected by higher rates of CLD, CLD or death, and oxygen dependency at discharge in preterm infants.",
keywords = "Chronic lung disease, Intrauterine growth restriction, Prematurity",
author = "Arun Sasi and Vinita Abraham and Miranda Davies-Tuck and Graeme Polglase and Graham Jenkin and Miller, {Suzanne Lee} and Atul Malhotra",
year = "2015",
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Impact of intrauterine growth restriction on preterm lung disease. / Sasi, Arun; Abraham, Vinita; Davies-Tuck, Miranda; Polglase, Graeme; Jenkin, Graham; Miller, Suzanne Lee; Malhotra, Atul.

In: Acta Paediatrica, Vol. 104, No. 12, 01.12.2015, p. e552 - e556.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Impact of intrauterine growth restriction on preterm lung disease

AU - Sasi, Arun

AU - Abraham, Vinita

AU - Davies-Tuck, Miranda

AU - Polglase, Graeme

AU - Jenkin, Graham

AU - Miller, Suzanne Lee

AU - Malhotra, Atul

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Aim Intrauterine growth restriction (IUGR) is an important cause for prematurity and adversely influences prematurity-related morbidities. This study evaluates the impact of IUGR on respiratory outcomes in infants <32 weeks with IUGR and birthweight <10th centile (SGA) compared to matched appropriate for gestation (AGA) controls. Methods The primary outcomes of this retrospective study are short-term pulmonary outcomes of chronic lung disease (CLD), CLD or death, and need for home oxygen at discharge. Subgroup analysis by gestation-based stratification (<28 and ≥28 <32 weeks) was decided a priori. Results Total of 153 IUGR and 306 non-IUGR infants were enrolled. The rate of CLD (45% vs. 17%, p = 0.0001), death (16% vs. 4.6%, p = 0.0001), CLD or death (46% vs. 21.5%, p = 0.0001), home oxygen rates (13.7% vs. 6.5%, p = 0.01) and duration of respiratory support was significantly higher in the IUGR group. IUGR emerged as the strongest predictor of CLD (adjusted OR, 95%CI: (8.4 [2, 35]) and CLD or death (12.7 [3, 54]) across all gestation. Conclusion IUGR is a major risk factor for adverse short-term pulmonary outcomes as reflected by higher rates of CLD, CLD or death, and oxygen dependency at discharge in preterm infants.

AB - Aim Intrauterine growth restriction (IUGR) is an important cause for prematurity and adversely influences prematurity-related morbidities. This study evaluates the impact of IUGR on respiratory outcomes in infants <32 weeks with IUGR and birthweight <10th centile (SGA) compared to matched appropriate for gestation (AGA) controls. Methods The primary outcomes of this retrospective study are short-term pulmonary outcomes of chronic lung disease (CLD), CLD or death, and need for home oxygen at discharge. Subgroup analysis by gestation-based stratification (<28 and ≥28 <32 weeks) was decided a priori. Results Total of 153 IUGR and 306 non-IUGR infants were enrolled. The rate of CLD (45% vs. 17%, p = 0.0001), death (16% vs. 4.6%, p = 0.0001), CLD or death (46% vs. 21.5%, p = 0.0001), home oxygen rates (13.7% vs. 6.5%, p = 0.01) and duration of respiratory support was significantly higher in the IUGR group. IUGR emerged as the strongest predictor of CLD (adjusted OR, 95%CI: (8.4 [2, 35]) and CLD or death (12.7 [3, 54]) across all gestation. Conclusion IUGR is a major risk factor for adverse short-term pulmonary outcomes as reflected by higher rates of CLD, CLD or death, and oxygen dependency at discharge in preterm infants.

KW - Chronic lung disease

KW - Intrauterine growth restriction

KW - Prematurity

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SP - e552 - e556

JO - Acta Paediatrica

JF - Acta Paediatrica

SN - 0803-5253

IS - 12

ER -