Abstract
Background: The variability in the effectiveness of type 2 diabetes (T2D) preventive interventions highlights the potential to identify the factors that determine treatment responses and those that would benefit the most from a given intervention. We conducted a systematic review to synthesize the evidence to support whether sociodemographic, clinical, behavioral, and molecular factors modify the efficacy of dietary or lifestyle interventions to prevent T2D. Methods: We searched MEDLINE, Embase, and Cochrane databases for studies reporting on the effect of a lifestyle, dietary pattern, or dietary supplement interventions on the incidence of T2D and reporting the results stratified by any effect modifier. We extracted relevant statistical findings and qualitatively synthesized the evidence for each modifier based on the direction of findings reported in available studies. We used the Diabetes Canada Clinical Practice Scale to assess the certainty of the evidence for a given effect modifier. Results: The 81 publications that met our criteria for inclusion are from 33 unique trials. The evidence is low to very low to attribute variability in intervention effectiveness to individual characteristics such as age, sex, BMI, race/ethnicity, socioeconomic status, baseline behavioral factors, or genetic predisposition. Conclusions: We report evidence, albeit low certainty, that those with poorer health status, particularly those with prediabetes at baseline, tend to benefit more from T2D prevention strategies compared to healthier counterparts. Our synthesis highlights the need for purposefully designed clinical trials to inform whether individual factors influence the success of T2D prevention strategies.
Original language | English |
---|---|
Article number | 133 |
Number of pages | 17 |
Journal | Communications Medicine |
Volume | 3 |
Issue number | 1 |
DOIs | |
Publication status | Published - 5 Oct 2023 |
Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
}
In: Communications Medicine, Vol. 3, No. 1, 133, 05.10.2023.
Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development
T2 - a systematic review
AU - Bodhini, Dhanasekaran
AU - Morton, Robert W.
AU - Santhakumar, Vanessa
AU - Nakabuye, Mariam
AU - Pomares-Millan, Hugo
AU - Clemmensen, Christoffer
AU - Fitzpatrick, Stephanie L.
AU - Guasch-Ferre, Marta
AU - Pankow, James S.
AU - Ried-Larsen, Mathias
AU - Franks, Paul W.
AU - Rich, Stephen S.
AU - Wagner, Robert
AU - Vilsbøll, Tina
AU - Vesco, Kimberly K.
AU - Udler, Miriam S.
AU - Tuomi, Tiinamaija
AU - Sweeting, Arianne
AU - Sims, Emily K.
AU - Sherr, Jennifer L.
AU - Semple, Robert K.
AU - Reynolds, Rebecca M.
AU - Redondo, Maria J.
AU - Redman, Leanne M.
AU - Pratley, Richard E.
AU - Pop-Busui, Rodica
AU - Pollin, Toni I.
AU - Perng, Wei
AU - Pearson, Ewan R.
AU - Ozanne, Susan E.
AU - Owen, Katharine R.
AU - Oram, Richard
AU - Murphy, Rinki
AU - Misra, Shivani
AU - Meigs, James B.
AU - Mathioudakis, Nestoras
AU - Mathieu, Chantal
AU - Ma, Ronald C.W.
AU - Lim, Siew S.
AU - Laffel, Lori M.
AU - Kwak, Soo Heon
AU - Josefson, Jami L.
AU - Hood, Korey K.
AU - Hivert, Marie France
AU - Hirsch, Irl B.
AU - Hattersley, Andrew T.
AU - Griffin, Kurt
AU - Greeley, Siri Atma W.
AU - Gottlieb, Peter A.
AU - Gomez, Maria F.
AU - Gloyn, Anna L.
AU - Florez, Jose C.
AU - Dennis, John M.
AU - Costacou, Tina
AU - Boyle, Kristen
AU - Billings, Liana K.
AU - Brown, Rebecca J.
AU - Philipson, Louis H.
AU - Nolan, John J.
AU - Eckel, Robert H.
AU - Sherifali, Diana
AU - Mixter, Emily
AU - Mekonnen, Eskedar Getie
AU - Gruber, Chandra
AU - Fawcett, Andrea J.
AU - de Souza, Russell
AU - Auh, Sungyoung
AU - Zhu, Yeyi
AU - Zhang, Cuilin
AU - Saint-Martin, Cécile
AU - Provenzano, Michele
AU - Pomares-Millan, Hugo
AU - Njølstad, Pål Rasmus
AU - Molnes, Janne
AU - McGovern, Andrew
AU - Maloney, Kristin A.
AU - Flanagan, Sarah E.
AU - de Franco, Elisa
AU - Aukrust, Ingvild
AU - Polak, Michel
AU - Beltrand, Jacques
AU - Zhou, Shao J.
AU - Zhang, Yingchai
AU - Yu, Gechang
AU - White, Sara L.
AU - Hannah, Wesley
AU - Wentworth, John M.
AU - Vatier, Camille
AU - Van der Schueren, Bart
AU - Urazbayeva, Marzhan
AU - Ukke, Gebresilasea Gendisha
AU - Tye, Sok Cin
AU - Taylor, Rachael
AU - Støy, Julie
AU - Stefan, Norbert
AU - Steck, Andrea K.
AU - Steenackers, Nele
AU - Stanislawski, Maggie A.
AU - Speake, Cate
AU - Sheu, Wayne Huey Herng
AU - Selvin, Elizabeth
AU - Scholtens, Denise M.
AU - Monaco, Gabriela S.F.
AU - Sarkar, Sudipa
AU - Kanbour, Sarah
AU - Saeed, Zeb
AU - Ray, Debashree
AU - Jain, Rashmi
AU - Quinteros, Alejandra
AU - Powe, Camille E.
AU - Petrie, John R.
AU - Perez, Dianna
AU - Pazmino, Sofia
AU - Pathirana, Maleesa
AU - Onengut-Gumuscu, Suna
AU - Motala, Ayesha A.
AU - Lowe, William L.
AU - Long, S. Alice
AU - Liu, Kai
AU - Libman, Ingrid M.
AU - Leung, Gloria K.W.
AU - Leong, Aaron
AU - Koivula, Robert W.
AU - Jones, Angus G.
AU - Johnson, Randi K.
AU - Hoag, Benjamin
AU - Ismail, Heba M.
AU - Harris-Kawano, Arianna
AU - Huang, Chuiguo
AU - Hansen, Torben
AU - Habibi, Nahal
AU - Guasch-Ferré, Marta
AU - Grieger, Jessica A.
AU - Goodarzi, Mark O.
AU - Gitelman, Stephen E.
AU - Fitipaldi, Hugo
AU - Fernández-Balsells, María Mercè
AU - Evans-Molina, Carmella
AU - Dudenhöffer-Pfeifer, Monika
AU - DiMeglio, Linda A.
AU - Dickens, Laura T.
AU - Deutsch, Aaron J.
AU - Dawed, Adem Y.
AU - Dabelea, Dana
AU - Chivers, Sian C.
AU - Chikowore, Tinashe
AU - Cheng, Feifei
AU - Chen, Mingling
AU - Bonham, Maxine P.
AU - Andersen, Mette K.
AU - Amouyal, Chloé
AU - Young, Katherine
AU - Yamamoto, Jennifer M.
AU - Wong, Jessie J.
AU - Wang, Caroline C.
AU - Wallace, Amelia S.
AU - Tosur, Mustafa
AU - Thuesen, Anne Cathrine B.
AU - Tam, Claudia Ha ting
AU - Takele, Wubet Worku
AU - Svalastoga, Pernille
AU - Sevilla-Gonzalez, Magdalena
AU - Semnani-Azad, Zhila
AU - Schön, Martin
AU - Rooney, Mary R.
AU - Raghavan, Sridharan
AU - Prystupa, Katsiaryna
AU - Pilla, Scott J.
AU - Patel, Kashyap Amratlal
AU - Ozkan, Bige
AU - Naylor, Rochelle N.
AU - Most, Jasper
AU - Morieri, Mario Luca
AU - Miller, Rachel G.
AU - Mclennan, Niamh Maire
AU - Massey, Robert
AU - Männistö, Jonna M.E.
AU - Lim, Lee Ling
AU - Kreienkamp, Raymond J.
AU - Kettunen, Jarno L.T.
AU - Kahkoska, Anna R.
AU - Jacobsen, Laura M.
AU - Ikle, Jennifer M.
AU - Hughes, Alice
AU - Haider, Eram
AU - Gaillard, Romy
AU - Gingras, Véronique
AU - Gillard, Pieter
AU - Francis, Ellen C.
AU - Felton, Jamie L.
AU - Duan, Daisy
AU - Cromer, Sara J.
AU - Corcoy, Rosa
AU - Colclough, Kevin
AU - Clark, Amy L.
AU - Bodhini, Dhanasekaran
AU - Benham, Jamie L.
AU - Aiken, Catherine
AU - Ahmad, Abrar
AU - ADA/EASD PMDI
AU - Tobias, Deirdre K.
AU - Merino, Jordi
AU - Mohan, Viswanathan Krishna
AU - Loos, Ruth J.F.
N1 - Publisher Copyright: © The Author(s) 2023.
PY - 2023/10/5
Y1 - 2023/10/5
N2 - Background: The variability in the effectiveness of type 2 diabetes (T2D) preventive interventions highlights the potential to identify the factors that determine treatment responses and those that would benefit the most from a given intervention. We conducted a systematic review to synthesize the evidence to support whether sociodemographic, clinical, behavioral, and molecular factors modify the efficacy of dietary or lifestyle interventions to prevent T2D. Methods: We searched MEDLINE, Embase, and Cochrane databases for studies reporting on the effect of a lifestyle, dietary pattern, or dietary supplement interventions on the incidence of T2D and reporting the results stratified by any effect modifier. We extracted relevant statistical findings and qualitatively synthesized the evidence for each modifier based on the direction of findings reported in available studies. We used the Diabetes Canada Clinical Practice Scale to assess the certainty of the evidence for a given effect modifier. Results: The 81 publications that met our criteria for inclusion are from 33 unique trials. The evidence is low to very low to attribute variability in intervention effectiveness to individual characteristics such as age, sex, BMI, race/ethnicity, socioeconomic status, baseline behavioral factors, or genetic predisposition. Conclusions: We report evidence, albeit low certainty, that those with poorer health status, particularly those with prediabetes at baseline, tend to benefit more from T2D prevention strategies compared to healthier counterparts. Our synthesis highlights the need for purposefully designed clinical trials to inform whether individual factors influence the success of T2D prevention strategies.
AB - Background: The variability in the effectiveness of type 2 diabetes (T2D) preventive interventions highlights the potential to identify the factors that determine treatment responses and those that would benefit the most from a given intervention. We conducted a systematic review to synthesize the evidence to support whether sociodemographic, clinical, behavioral, and molecular factors modify the efficacy of dietary or lifestyle interventions to prevent T2D. Methods: We searched MEDLINE, Embase, and Cochrane databases for studies reporting on the effect of a lifestyle, dietary pattern, or dietary supplement interventions on the incidence of T2D and reporting the results stratified by any effect modifier. We extracted relevant statistical findings and qualitatively synthesized the evidence for each modifier based on the direction of findings reported in available studies. We used the Diabetes Canada Clinical Practice Scale to assess the certainty of the evidence for a given effect modifier. Results: The 81 publications that met our criteria for inclusion are from 33 unique trials. The evidence is low to very low to attribute variability in intervention effectiveness to individual characteristics such as age, sex, BMI, race/ethnicity, socioeconomic status, baseline behavioral factors, or genetic predisposition. Conclusions: We report evidence, albeit low certainty, that those with poorer health status, particularly those with prediabetes at baseline, tend to benefit more from T2D prevention strategies compared to healthier counterparts. Our synthesis highlights the need for purposefully designed clinical trials to inform whether individual factors influence the success of T2D prevention strategies.
UR - http://www.scopus.com/inward/record.url?scp=85173475719&partnerID=8YFLogxK
U2 - 10.1038/s43856-023-00363-0
DO - 10.1038/s43856-023-00363-0
M3 - Article
C2 - 37794109
AN - SCOPUS:85173475719
SN - 2730-664X
VL - 3
JO - Communications Medicine
JF - Communications Medicine
IS - 1
M1 - 133
ER -