Impact of CYP2C19 genotype-predicted enzyme activity on hippocampal volume, anxiety, and depression

Aisouda Savadlou; Aurina Arnatkeviciute; Jeggan Tiego; Ziarih Hawi; Mark A. Bellgrove; Alex Fornito; Chad Bousman

doi:10.1016/j.psychres.2020.112984

Impact of CYP2C19 genotype-predicted enzyme activity on hippocampal volume, anxiety, and depression

Aisouda Savadlou, Aurina Arnatkeviciute, Jeggan Tiego, Ziarih Hawi, Mark A. Bellgrove, Alex Fornito, Chad Bousman

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

Cytochrome P450 C19 (CYP2C19) metabolizes exogenous and endogenous compounds. Although CYP2C19 is highly expressed in the liver, it is also expressed in the brain during early life. Previous human and animal studies have linked CYP2C19 genotype-predicted enzyme activity to hippocampal volumes, depressive symptoms, and anxiety-like behaviors. We examined these promising associations in a general community sample comprising 386 Caucasian adults with no history of psychiatric or neurological illnesses. Contrary to previous findings, CYP2C19 genotype-predicted enzyme activity was not associated with hippocampal volumes, nor depressive and anxiety symptoms. Interstudy differences in CYP2C19 frequencies and/or study methodology may explain this discrepancy.

Original language	English
Article number	112984
Number of pages	4
Journal	Psychiatry Research
Volume	288
DOIs	https://doi.org/10.1016/j.psychres.2020.112984
Publication status	Published - Jun 2020

Keywords

CYP2C19
Hippocampus
Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.psychres.2020.112984

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title = "Impact of CYP2C19 genotype-predicted enzyme activity on hippocampal volume, anxiety, and depression",

abstract = "Cytochrome P450 C19 (CYP2C19) metabolizes exogenous and endogenous compounds. Although CYP2C19 is highly expressed in the liver, it is also expressed in the brain during early life. Previous human and animal studies have linked CYP2C19 genotype-predicted enzyme activity to hippocampal volumes, depressive symptoms, and anxiety-like behaviors. We examined these promising associations in a general community sample comprising 386 Caucasian adults with no history of psychiatric or neurological illnesses. Contrary to previous findings, CYP2C19 genotype-predicted enzyme activity was not associated with hippocampal volumes, nor depressive and anxiety symptoms. Interstudy differences in CYP2C19 frequencies and/or study methodology may explain this discrepancy.",

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T1 - Impact of CYP2C19 genotype-predicted enzyme activity on hippocampal volume, anxiety, and depression

AU - Savadlou, Aisouda

AU - Arnatkeviciute, Aurina

AU - Tiego, Jeggan

AU - Hawi, Ziarih

AU - Bellgrove, Mark A.

AU - Fornito, Alex

AU - Bousman, Chad

PY - 2020/6

Y1 - 2020/6

N2 - Cytochrome P450 C19 (CYP2C19) metabolizes exogenous and endogenous compounds. Although CYP2C19 is highly expressed in the liver, it is also expressed in the brain during early life. Previous human and animal studies have linked CYP2C19 genotype-predicted enzyme activity to hippocampal volumes, depressive symptoms, and anxiety-like behaviors. We examined these promising associations in a general community sample comprising 386 Caucasian adults with no history of psychiatric or neurological illnesses. Contrary to previous findings, CYP2C19 genotype-predicted enzyme activity was not associated with hippocampal volumes, nor depressive and anxiety symptoms. Interstudy differences in CYP2C19 frequencies and/or study methodology may explain this discrepancy.

AB - Cytochrome P450 C19 (CYP2C19) metabolizes exogenous and endogenous compounds. Although CYP2C19 is highly expressed in the liver, it is also expressed in the brain during early life. Previous human and animal studies have linked CYP2C19 genotype-predicted enzyme activity to hippocampal volumes, depressive symptoms, and anxiety-like behaviors. We examined these promising associations in a general community sample comprising 386 Caucasian adults with no history of psychiatric or neurological illnesses. Contrary to previous findings, CYP2C19 genotype-predicted enzyme activity was not associated with hippocampal volumes, nor depressive and anxiety symptoms. Interstudy differences in CYP2C19 frequencies and/or study methodology may explain this discrepancy.

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KW - Hippocampus

KW - Metabolism

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Impact of CYP2C19 genotype-predicted enzyme activity on hippocampal volume, anxiety, and depression

Abstract

Keywords

UN SDGs

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Functional characterisation of genetic risk variants for ADHD: from Association to Biology

Cite this

Impact of CYP2C19 genotype-predicted enzyme activity on hippocampal volume, anxiety, and depression

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

Functional characterisation of genetic risk variants for ADHD: from Association to Biology

Cite this