Impact of cytokines and T lymphocytes upon osteoclast differentiation and function

Research output: Contribution to journalComment / DebateOtherpeer-review

63 Citations (Scopus)


Historically, the osteoblast has been considered the master cell in the control of osteoclast development and, therefore, bone resorption. Now the interactions between cells of the immune system and bone cells have redefined our thinking on the regulation of bone resorption. Moreover, the crosstalk between these cell types has special significance in inflammatory conditions such as rheumatoid arthritis. This report highlights the contribution that T lymphocytes make in regulating osteoclast formation and bone resorption.

Original languageEnglish
Article number103
Number of pages3
JournalArthritis Research and Therapy
Issue number2
Publication statusPublished - 21 Mar 2007
Externally publishedYes

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