Impact of antibiotics-induced gut microbiota changes on bone regeneration in murine calvarial defects

Loh Teng-Hern Tan; Bingpeng Lin; Vengadesh Letchumanan; Jodi Woan-Fei Law; Learn-Han Lee

doi:10.1136/gutjnl-2024-IDDF.100

Impact of antibiotics-induced gut microbiota changes on bone regeneration in murine calvarial defects

Loh Teng-Hern Tan, Bingpeng Lin, Vengadesh Letchumanan, Jodi Woan-Fei Law, Learn-Han Lee

Malaysia Jeffrey Cheah Sch of Med & HS

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

Gut microbiota has been shown to be an important regulator of health and development. The intestinal flora can maintain the homeostasis of the host immune system, participate in the regulation of osteoclast and osteoblast activity, and affect the body’s bone remodeling. This study aims to elucidate the link between gut microbiota and bone healing in murine calvarial defects, focusing on the effect of antibiotic-induced gut microbiota dysbiosis.

Original language	English
Article number	IDDF2024-ABS-0236
Pages (from-to)	A159-A160
Number of pages	2
Journal	Gut
Volume	73
Issue number	S2
DOIs	https://doi.org/10.1136/gutjnl-2024-IDDF.100
Publication status	Published - Aug 2024
Event	International Digestive Disease Forum 2024 - , Hong Kong Duration: 10 Aug 2024 → 11 Aug 2024 https://gut.bmj.com/content/73/Suppl_2 (published abstracts)

Access to Document

10.1136/gutjnl-2024-IDDF.100

Cite this

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title = "Impact of antibiotics-induced gut microbiota changes on bone regeneration in murine calvarial defects",

abstract = "Gut microbiota has been shown to be an important regulator of health and development. The intestinal flora can maintain the homeostasis of the host immune system, participate in the regulation of osteoclast and osteoblast activity, and affect the body{\textquoteright}s bone remodeling. This study aims to elucidate the link between gut microbiota and bone healing in murine calvarial defects, focusing on the effect of antibiotic-induced gut microbiota dysbiosis.",

author = "Tan, {Loh Teng-Hern} and Bingpeng Lin and Vengadesh Letchumanan and Law, {Jodi Woan-Fei} and Learn-Han Lee",

year = "2024",

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pages = "A159--A160",

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issn = "0017-5749",

publisher = "BMJ",

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note = "International Digestive Disease Forum 2024, IDDF 2024 ; Conference date: 10-08-2024 Through 11-08-2024",

url = "https://gut.bmj.com/content/73/Suppl_2",

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T1 - Impact of antibiotics-induced gut microbiota changes on bone regeneration in murine calvarial defects

AU - Tan, Loh Teng-Hern

AU - Lin, Bingpeng

AU - Letchumanan, Vengadesh

AU - Law, Jodi Woan-Fei

AU - Lee, Learn-Han

PY - 2024/8

Y1 - 2024/8

N2 - Gut microbiota has been shown to be an important regulator of health and development. The intestinal flora can maintain the homeostasis of the host immune system, participate in the regulation of osteoclast and osteoblast activity, and affect the body’s bone remodeling. This study aims to elucidate the link between gut microbiota and bone healing in murine calvarial defects, focusing on the effect of antibiotic-induced gut microbiota dysbiosis.

AB - Gut microbiota has been shown to be an important regulator of health and development. The intestinal flora can maintain the homeostasis of the host immune system, participate in the regulation of osteoclast and osteoblast activity, and affect the body’s bone remodeling. This study aims to elucidate the link between gut microbiota and bone healing in murine calvarial defects, focusing on the effect of antibiotic-induced gut microbiota dysbiosis.

U2 - 10.1136/gutjnl-2024-IDDF.100

DO - 10.1136/gutjnl-2024-IDDF.100

M3 - Meeting Abstract

SN - 0017-5749

VL - 73

SP - A159-A160

JO - Gut

JF - Gut

IS - S2

M1 - IDDF2024-ABS-0236

T2 - International Digestive Disease Forum 2024

Y2 - 10 August 2024 through 11 August 2024

ER -