Projects per year
Abstract
Background: Allogeneic hematopoietic stem cell transplantation (HSCT) can lead to significant changes to the HIV reservoir and HIV immune responses, indicating that further characterization of HIV-infected patients undergoing HSCT is warranted. Methods: We studied 3 patients who underwent HSCT after either reduced intensity conditioning or myeloablative conditioning regimen. We measured HIV antigens and antibodies (Ag/Ab), HIV-specific CD4 + T-cell responses, HIV RNA, and DNA in plasma, peripheral blood mononuclear cells, isolated CD4 + T cells from peripheral blood, and lymph node cells. The patients remained on antiretroviral therapy throughout the follow-up period. Results: All patients have been in continued remission for 4-6 years post-HSCT. Analyses of HIV RNA and DNA levels showed substantial reductions in HIV reservoir-related measurements in all 3 patients, changes in immune response varied with pronounced reductions in 2 patients and a less dramatic reduction in 1 patient. One patient experienced unexpected viral rebound 4 years after HSCT. Conclusions: These 3 cases highlight the substantial changes to the HIV reservoir and the HIV immune response in patients undergoing allogeneic HSCT. The viral rebound observed in 1 patient indicates that replication competent HIV can re-emerge several years after HSCT despite these marked changes.
Original language | English |
---|---|
Pages (from-to) | 328-337 |
Number of pages | 10 |
Journal | JAIDS |
Volume | 75 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Jul 2017 |
Keywords
- HIV
- immune response
- reservoirs
- stem cell transplant
- stem cells
Projects
- 1 Curtailed
-
HIV latency, pathogenesis and immunity
Cooper, D. A., Davenport, M., Emery, S., Kelleher, A., Kent, S., Lewin, S. & Purcell, D. F. J.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/14 → 1/07/14
Project: Research