Immunosuppression increases latent infection of brain by JC polyomavirus

Julianne Bayliss; Tania Karasoulos; Scott Bowden; Ivana Glogowski; Catriona Ann McLean

doi:10.1097/PAT.0b013e3283463558

Immunosuppression increases latent infection of brain by JC polyomavirus

Julianne Bayliss, Tania Karasoulos, Scott Bowden, Ivana Glogowski, Catriona Ann McLean

Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

23 Citations (Scopus)

Abstract

Brain and kidney tissue from 138 non-PML patients (78 immunocompetent; 60 immunosuppressed) was assessed for JCV large T (LT) and viral protein (VP)1 DNA with nested PCR. Immunohistochemistry was performed to detect presence of JCV protein. Autopsy findings were reviewed and all brains underwent neuropathological examination

Original language	English
Pages (from-to)	362 - 367
Number of pages	6
Journal	Pathology
Volume	43
Issue number	4
DOIs	https://doi.org/10.1097/PAT.0b013e3283463558
Publication status	Published - 2011

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10.1097/PAT.0b013e3283463558

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title = "Immunosuppression increases latent infection of brain by JC polyomavirus",

abstract = "Brain and kidney tissue from 138 non-PML patients (78 immunocompetent; 60 immunosuppressed) was assessed for JCV large T (LT) and viral protein (VP)1 DNA with nested PCR. Immunohistochemistry was performed to detect presence of JCV protein. Autopsy findings were reviewed and all brains underwent neuropathological examination",

author = "Julianne Bayliss and Tania Karasoulos and Scott Bowden and Ivana Glogowski and McLean, {Catriona Ann}",

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T1 - Immunosuppression increases latent infection of brain by JC polyomavirus

AU - Bayliss, Julianne

AU - Karasoulos, Tania

AU - Bowden, Scott

AU - Glogowski, Ivana

AU - McLean, Catriona Ann

PY - 2011

Y1 - 2011

N2 - Brain and kidney tissue from 138 non-PML patients (78 immunocompetent; 60 immunosuppressed) was assessed for JCV large T (LT) and viral protein (VP)1 DNA with nested PCR. Immunohistochemistry was performed to detect presence of JCV protein. Autopsy findings were reviewed and all brains underwent neuropathological examination

AB - Brain and kidney tissue from 138 non-PML patients (78 immunocompetent; 60 immunosuppressed) was assessed for JCV large T (LT) and viral protein (VP)1 DNA with nested PCR. Immunohistochemistry was performed to detect presence of JCV protein. Autopsy findings were reviewed and all brains underwent neuropathological examination

UR - http://journals.lww.com/pathologyrcpa/pages/articleviewer.aspx?year=2011&issue=06000&article=00012&type=abstract

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DO - 10.1097/PAT.0b013e3283463558

M3 - Article

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SP - 362

EP - 367

JO - Pathology

JF - Pathology

SN - 0031-3025

IS - 4

ER -

Immunosuppression increases latent infection of brain by JC polyomavirus

Abstract

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