Immunosuppression and risk of cervical cancer

Pierre Antoine Dugué, Matejka Rebolj, Peter Garred, Elsebeth Lynge

Research output: Contribution to journalReview ArticleResearchpeer-review

35 Citations (Scopus)

Abstract

A markedly increased risk of cervical cancer is known in women immunosuppressed due to AIDS or therapy following organ transplantation. The aim of this review is to determine the association between other conditions affecting the immune system and the risk of cervical cancer. Patients with end-stage renal disease seem to be at an increased risk of cervical cancer. A higher risk of cervical precancerous lesions was found in patients with some autoimmune diseases; particularly if treated with immunosuppressants. Among behavioral factors weakening the immune system, smoking appeared to strongly increase the risk of cervical cancer, while poor diet only moderately increased the risk. It is difficult to determine whether sexually transmitted infections other than human papillomavirus infection are independent risk factors. Identifying those groups of women likely to fail in clearing persistent human papillomavirus infections would help individualize screening guidelines and target immune-associated factors in the cervical cancer etiology.

Original languageEnglish
Pages (from-to)29-42
Number of pages14
JournalExpert Review of Anticancer Therapy
Volume13
Issue number1
DOIs
Publication statusPublished - 1 Jan 2013
Externally publishedYes

Keywords

  • autoimmune diseases
  • cervical cancer
  • diet
  • end-stage renal disease
  • HIV/AIDS
  • immunosuppression
  • inflammatory bowel disease
  • organ transplantation
  • sexually transmitted infections
  • smoking
  • systemic lupus erythematosus

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