|Title of host publication||Encyclopaedia of AIDS|
|Editors||Thomas J. Hope, Mario Stevenson, Douglas Richman|
|Place of Publication||New York NY USA|
|Number of pages||15|
|Publication status||Published - 2014|
HIV-infected patients, particularly those with advanced immunodeficiency, are frequently coinfected with other common and opportunistic infections. Here, we discuss the immunopathogenesis of six common infections that cause significant morbidity in HIV-infected patients globally. These include coinfection with cytomegalovirus (CMV), Mycobacterium tuberculosis, Cryptococcus neoformans, hepatitis B virus (HBV), hepatitis C virus (HCV), and Plasmodium falciparum. We summarize the epidemiology and global burden of each coinfection; highlight the immune response, pathogenesis, and natural history; and discuss the immune interplay between HIV and the co-pathogen and also the effect of cART in the setting of HIV coinfections, including the pathogenesis of immune restoration disease (IRD).