Immunopathogenesis of HIV co-infections

Christina C. Chang; Megan Crane; Anthony Jaworowski; Andrew Lloyd; Martyn A. French; Sharon R. Lewin

doi:10.1007/978-1-4614-9610-6_179-1

Immunopathogenesis of HIV co-infections

Christina C. Chang, Megan Crane, Anthony Jaworowski, Andrew Lloyd, Martyn A. French, Sharon R. Lewin

Research output: Chapter in Book/Report/Conference proceeding › Encyclopaedia / Dictionary Entry › Other › peer-review

Abstract

HIV-infected patients, particularly those with advanced immunodeficiency, are frequently coinfected with other common and opportunistic infections. Here, we discuss the immunopathogenesis of six common infections that cause significant morbidity in HIV-infected patients globally. These include coinfection with cytomegalovirus (CMV), Mycobacterium tuberculosis, Cryptococcus neoformans, hepatitis B virus (HBV), hepatitis C virus (HCV), and Plasmodium falciparum. We summarize the epidemiology and global burden of each coinfection; highlight the immune response, pathogenesis, and natural history; and discuss the immune interplay between HIV and the co-pathogen and also the effect of cART in the setting of HIV coinfections, including the pathogenesis of immune restoration disease (IRD).

Original language	English
Title of host publication	Encyclopaedia of AIDS
Editors	Thomas J. Hope, Mario Stevenson, Douglas Richman
Place of Publication	New York NY USA
Publisher	Springer
Number of pages	15
ISBN (Electronic)	978-1-4614-9610-6
DOIs	https://doi.org/10.1007/978-1-4614-9610-6_179-1
Publication status	Published - 2014

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10.1007/978-1-4614-9610-6_179-1

Cite this

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title = "Immunopathogenesis of HIV co-infections",

abstract = "HIV-infected patients, particularly those with advanced immunodeficiency, are frequently coinfected with other common and opportunistic infections. Here, we discuss the immunopathogenesis of six common infections that cause significant morbidity in HIV-infected patients globally. These include coinfection with cytomegalovirus (CMV), Mycobacterium tuberculosis, Cryptococcus neoformans, hepatitis B virus (HBV), hepatitis C virus (HCV), and Plasmodium falciparum. We summarize the epidemiology and global burden of each coinfection; highlight the immune response, pathogenesis, and natural history; and discuss the immune interplay between HIV and the co-pathogen and also the effect of cART in the setting of HIV coinfections, including the pathogenesis of immune restoration disease (IRD).",

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Immunopathogenesis of HIV co-infections. / Chang, Christina C.; Crane, Megan; Jaworowski, Anthony; Lloyd, Andrew; French, Martyn A.; Lewin, Sharon R.

Encyclopaedia of AIDS. ed. / Thomas J. Hope; Mario Stevenson; Douglas Richman. New York NY USA : Springer, 2014.

Research output: Chapter in Book/Report/Conference proceeding › Encyclopaedia / Dictionary Entry › Other › peer-review

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AB - HIV-infected patients, particularly those with advanced immunodeficiency, are frequently coinfected with other common and opportunistic infections. Here, we discuss the immunopathogenesis of six common infections that cause significant morbidity in HIV-infected patients globally. These include coinfection with cytomegalovirus (CMV), Mycobacterium tuberculosis, Cryptococcus neoformans, hepatitis B virus (HBV), hepatitis C virus (HCV), and Plasmodium falciparum. We summarize the epidemiology and global burden of each coinfection; highlight the immune response, pathogenesis, and natural history; and discuss the immune interplay between HIV and the co-pathogen and also the effect of cART in the setting of HIV coinfections, including the pathogenesis of immune restoration disease (IRD).

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