Immunopathogenesis of HIV co-infections

Christina C. Chang, Megan Crane, Anthony Jaworowski, Andrew Lloyd, Martyn A. French, Sharon R. Lewin

Research output: Chapter in Book/Report/Conference proceedingEncyclopaedia / Dictionary EntryOtherpeer-review


HIV-infected patients, particularly those with advanced immunodeficiency, are frequently coinfected with other common and opportunistic infections. Here, we discuss the immunopathogenesis of six common infections that cause significant morbidity in HIV-infected patients globally. These include coinfection with cytomegalovirus (CMV), Mycobacterium tuberculosis, Cryptococcus neoformans, hepatitis B virus (HBV), hepatitis C virus (HCV), and Plasmodium falciparum. We summarize the epidemiology and global burden of each coinfection; highlight the immune response, pathogenesis, and natural history; and discuss the immune interplay between HIV and the co-pathogen and also the effect of cART in the setting of HIV coinfections, including the pathogenesis of immune restoration disease (IRD).
Original languageEnglish
Title of host publicationEncyclopaedia of AIDS
EditorsThomas J. Hope, Mario Stevenson, Douglas Richman
Place of PublicationNew York NY USA
Number of pages15
ISBN (Electronic)978-1-4614-9610-6
Publication statusPublished - 2014

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